丸线粒体的氧化还原失衡和氧化酸化受损是Wistar大鼠中微塑料诱导的丸功能障碍的基础
Samuel Abiodun Kehinde1,2, Tolulope Peter Fatokun3, Sarva Mangala Praveena4
1Biomedical Technology Research Group for Vulnerable Populations and School of Health Science, Mae Fah Luang University, Chiang Rai, Thailand.
Frontiers in toxicology
|February 2, 2026
概括
聚乙烯微塑料通过损害线粒体能量生产和氧化还原平衡来破坏雄性大鼠丸功能,导致生殖毒性和不孕症. 这项研究阐明了微塑料诱导的男性生殖健康问题背后的机制.
科学领域:
- 环境毒理学环境毒理学
- 生殖生物学 生殖生物学
- 线粒体医学 线粒体医学
背景情况:
- 聚乙烯微塑料 (PE-MPs) 是广泛存在的环境污染物,疑似与男性生殖毒性有关.
- 精确的机制,PE-MPs影响丸功能,特别是线粒体过程,尚未完全理解.
研究的目的:
- 在Wistar大鼠中调查PE-MP诱导的雄性生殖毒性的机制基础.
- 检查PE-MPs对丸线粒体氧化还原稳定和氧化酸化的影响.
主要方法:
- 鼠被口服PE-MPs (15或60毫克/公斤) 或载体28天.
- 评估丸线粒体的生物能量,包括TCA循环酶和呼吸链复杂活动.
- 评估了线粒体氧化还原平衡标志物 (MDA,MPO,GSH,CAT,SOD) 和生殖终点 (组织病理学,水平).
主要成果:
- 根据剂量,PE-MP暴露抑制了TCA循环和电子运输链活动,显著影响了ATP合成.
- 线粒体功能障碍的证据是氧化应激标志物 (MDA,MPO) 的增加和抗氧化防御 (GSH,CAT,SOD) 的减少.
- 这些生物能和氧化还原损害与丸退化和降低丸激素水平相关.
结论:
- PE-MPs通过破坏氧化酸化和氧化还原平衡来损害丸的生物能量和功能.
- 这导致线粒体功能障碍,丸结构损伤和类固醇生成受损,导致男性不育.
- 这些发现提供了对微塑料生殖毒性的机制性见解,并强调了减少暴露的必要性.
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