跨直流刺激与慢性腰部疼痛的运动治疗相结合:系统性审查和元分析
Rui Xia1, Shihan Lu2, Lunan Zhao1
1College of Sports Science, Qufu Normal University, Qufu, China.
Frontiers in human neuroscience
|February 2, 2026
概括
将直流刺激 (tDCS) 与运动相结合,可以轻微但显著地降低慢性腰痛 (CLBP) 的强度. 更长的干预持续时间可能会改善CLBP患者的身体功能.
科学领域:
- 神经学 神经学
- 康复医学 康复医学 康复医学
- 疼痛管理 疼痛管理
背景情况:
- 慢性腰部疼痛 (CLBP) 显著影响生活质量,是导致残疾的主要原因.
- 目前对CLBP的治疗方法提供有限的益处.
- 超直流刺激 (tDCS) 显示出调节皮层刺激性和疼痛通路的潜力.
研究的目的:
- 系统地审查和元分析结合tDCS与成年人患有CLBP的结构化炼的附加效应.
- 量化tDCS增强运动对CLBP疼痛强度和身体功能的影响.
- 评估证据对这种联合干预的确定性.
主要方法:
- 搜索了主要的数据库 (PubMed,科学网,CENTRAL,Embase,CNKI) 相关的随机对照试验 (RCT).
- 包括RCT比较活跃的tDCS加运动与假的tDCS加运动在成年人患有CLBP (持续时间≥12周).
- 使用Cochrane RoB 2.0评估偏差风险和使用GRADE的证据确定性.
主要成果:
- 五个RCT (n=195) 被纳入了元分析.
- 发现tDCS在减少疼痛强度方面具有显著的附加效应 (WMD = -0.99,p=0.006).
- 对身体功能的影响是有利的,但在统计学上不显著 (SMD = -0.65,p=0.28),具有很高的异质性 (I2=90.7%).
结论:
- 阳道tDCS与运动相结合,可以轻微但显著地降低CLBP疼痛强度.
- 更长的干预持续时间可能会对功能结果产生积极影响.
- 需要进行更大规模,高质量的试验,以证实研究结果,并优化TLBP管理的tDCS参数.
相关概念视频
Directing Effect of Substituents: meta-Directing Groups
6.0K
Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
6.0K
Combination Therapies and Personalized Medicine
6.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.1K
meta-Directing Deactivators: –NO2, –CN, –CHO, –⁠CO2R, –COR, –CO2H
6.7K
All meta-directing substituents are deactivating groups. These substituents withdraw electrons from the aromatic ring, making the ring less reactive toward electrophilic substitution. For example, the nitration of nitrobenzene is 100,000 times slower than that of benzene because of the deactivating effect of the nitro group. The first step in an electrophilic aromatic substitution is the addition of an electrophile to form a resonance-stabilized carbocation. The energy diagrams for...
6.7K
Review and Preview
8.4K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview
11.3K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.3K
Mesh Analysis with Current Sources
2.0K
Mesh analysis becomes simpler when analyzing circuits with current sources, whether independent or dependent. The presence of current sources reduces the number of equations required for analysis. Two cases illustrate this:
Current Source in One Mesh: The analysis process is straightforward when a current source is found in only one mesh within the circuit. Mesh currents are assigned as usual, with the mesh containing the current source excluded from the analysis. Kirchhoff's voltage law...
Current Source in One Mesh: The analysis process is straightforward when a current source is found in only one mesh within the circuit. Mesh currents are assigned as usual, with the mesh containing the current source excluded from the analysis. Kirchhoff's voltage law...
2.0K


