肥胖引起的认知障碍:潜在的机制和治疗前景
Kai Liu1, Shu Liu2, Dong Wang3
1Department of Endocrinology, Second Hospital of Harbin, Harbin, 150000, Heilongjiang, China.
Metabolism open
|February 2, 2026
概括
全球肥胖率上升与认知能力下降有关,包括痴呆症和焦虑症. 了解这些联系对于开发有针对性的干预措施来保护大脑健康至关重要.
科学领域:
- 神经科学是一个神经科学.
- 代谢健康 代谢健康
- 公共卫生 公共卫生
背景情况:
- 全球肥胖患病率正在上升,超出代谢性疾病之外,存在重大风险.
- 中年肥胖与痴呆症,焦虑症和执行功能障碍等认知障碍有关.
- 肥胖和认知能力下降之间的联系机制包括神经炎症,肠道微生物群失调,代谢异常和阿迪波金失衡.
研究的目的:
- 探索肥胖和认知障碍之间的多方面的关系.
- 阐明导致肥胖的认知功能障碍的病理途径.
- 审查当前和未来的干预策略,以减轻与肥胖相关的认知风险.
主要方法:
- 对病理途径的审查,包括神经炎症,肠-大脑轴,代谢综合征和阿迪波金.
- 检查肥胖引起的炎症如何影响神经保护和神经退行.
- 分析肠道微生物群,短链脂肪酸和代谢综合征在认知功能中的作用.
主要成果:
- 肥胖引起的炎症激活了微质,增加了β-粉样蛋白沉积,并加剧了神经退行.
- 肠道失生症通过减少有益的短链脂肪酸生产,损害神经保护.
- 代谢综合征损害大脑血管和白质微观结构;遗传和种族因素调节这些影响.
结论:
- 肥胖通过复杂的生物途径显著影响认知功能.
- 诸如减肥手术,生活方式改变和药物等干预措施在改善认知结果方面表现有前途.
- 未来的研究应该专注于精确的,多维的生物标志物和优化肥胖评估,以实现个性化的预防和治疗.
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