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糖尿病病中的炎症机制:新兴见解和向治疗方法

Shengnan Lin^1,2, Zheng Shu², Mi Zhou³

¹Department of Endocrinology and Metabology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Institute of Nephrology, Jinan, Shandong, China.

Frontiers in medicine

|February 2, 2026

概括

糖尿病病 (DKD) 越来越多地与慢性炎症有关. 本综述探讨了新的炎症机制,诊断生物标志物,以及针对性治疗,如SGLT2抑制剂和ns-MRAs,以更好地管理DKD.

科学领域:

腎臟病學 (nephrology) 是一種醫學專業.
免疫学免疫学免疫学
遗传学是一个遗传学.

背景情况:

糖尿病病 (DKD) 是末期病 (ESRD) 的主要原因之一.
对DKD病变的理解已经转向强调慢性炎症的关键作用.
传统的代谢和血液动力学因素现在与炎症过程一起被看作是.

研究的目的:

系统地审查最近在DKD的炎症机制的进展.
讨论这些炎症机制的转化影响.
专注于新兴的诊断生物标志物和DKD的新型炎症向治疗策略.

主要方法:

关于DKD炎症机制的当前文献的综述.
对新兴诊断生物标志物和奥米克技术的分析.
评估针对炎症的新型治疗策略,包括SGLT2抑制剂,ns-MRA和GLP-1RA.
评估天然产品作为潜在的多目标干预措施.

主要成果:

DKD涉及复杂的炎症路径,细胞衰老,受损的皮细胞自,肠道微生物群-轴,以及非编码RNA调节.
使用欧米克和人工智能的新型诊断范式正在出现,与相关的生物标志物.
一些治疗药物,包括SGLT2抑制剂,ns-MRAs和GLP-1RAs,显示已证明的益.

结论:

DKD炎症是由复杂的局部和全身因素驱动的.
需要一个多方面的方法,整合多omics数据的炎症亚型.
涉及常规药物,向药物和天然化合物的联合疗法对推动DKD管理具有前景.

关键词:

作为GLP-1受体的激动剂.在NLRP3炎症酶体中,NLRP3炎症 SGLT2 抑制剂的使用.糖尿病病糖尿病病这是一种炎症炎症炎症炎症.多种主题的多种主题.非类固醇矿物质皮质类受体对抗剂病变的发生和发病.

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