初级胆道胆炎的唾液生物标志物的诊断潜力:一个系统的审查
Mahnoor Saeed1, Muhammad Saad Shaikh2, Alhanouf Binhezaim3
1Sindh Institute of Oral Health Sciences, Jinnah Sindh Medical University, Karachi, Pakistan.
Frontiers in medicine
|February 2, 2026
概括
唾液含有生物标志物,如抗线粒体抗体-M2 (AMA-M2) 和炎症性细胞因子,可以帮助诊断原发性胆道胆炎 (PBC). 需要进一步的研究来确认它们在临床上用于PBC诊断.
科学领域:
- 胃肠病学和自身免疫性疾病
- 生物标志物发现发现
- 唾液诊断 唾液诊断 唾液诊断
背景情况:
- 唾液越来越被认可用于诊断系统性和自身免疫性疾病.
- 唾液生物标志物对一次性胆道胆炎 (PBC) 的诊断效用尚未得到充分证实.
研究的目的:
- 系统地审查关于唾液生物标志物用于初级胆道胆道炎 (PBC) 诊断的文献.
主要方法:
- 我们对PubMed和Scopus数据库进行了系统的搜索.
- 包括用于PBC诊断的唾液生物标志物的原始横截面研究.
- 使用乔安娜·布里格斯研究所 (JBI) 检查清单进行质量评估.
主要成果:
- 包含了3项研究,其中有204名参与者.
- 在PBC患者中发现唾液AMA-M2,PDC-E2抗体和炎症性细胞因子 (IL-6,IL-17A,IFN-γ,TNF-α) 的升高.
- 蛋白质基因的改变,包括囊S型蛋白和S100A家族蛋白形,也使PBC有所差异化.
- 唾液AMA-M2和PDC-E2抗体显示出高的诊断特异性.
结论:
- 某些唾液自身抗体和炎症蛋白对PBC诊断有希望.
- 目前的证据有限,需要更大规模的标准化研究进行临床验证.
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