在活体捐赠者肝移植接受者的死亡率中,前素和C-反应蛋白的预测值
Saraswathy S1, Johns Shaji Mathew2, Anila Kn1
1Department of Gastrointestinal Surgery and Solid Organ Transplantation, Amrita Institute of Medical Sciences and Research Center, Amrita Vishwa Vidyapeetham, Kochi, IND.
Cureus
|February 2, 2026
概括
在活体供体肝移植 (LDLT) 后,甲素 (PCT) 和C反应蛋白 (CRP) 的趋势预测死亡率. 从术后第三天到第七天PCT和CRP水平上升表明LDLT患者的死亡风险较高.
科学领域:
- 移植免疫学 移植免疫学
- 临床生物化学 临床生物化学
- 传染病诊断 传染病诊断 传染病诊断
背景情况:
- 准确的生物标志物对于肝移植后的早期败血症诊断至关重要.
- 甲素 (PCT) 和C反应蛋白 (CRP) 是潜在的感染生物标志物.
- 活体供体肝移植 (LDLT) 在术后监测中提出了独特的挑战.
研究的目的:
- 评估PCT和CRP在LDLT后预测细菌感染的诊断准确性.
- 评估PCT和CRP趋势与LDLT后患者死亡率之间的相关性.
- 确定这些生物标志物的预后价值在早期的术后期.
主要方法:
- 在2021年1月至2022年12月期间,对成年LDLT患者的前性分析.
- 在术后第1,3,5和第7天对CRP和PCT进行序列测量.
- 在患有和没有感染的患者中比较生物标志物水平 (血液,尿路等). ) 的情况.
- 多变量逻辑回归分析生物标志物趋势对死亡率的影响.
主要成果:
- 绝对CRP和PCT值无法有效诊断LDLT后的感染.
- 没有感染的患者在术后第5天和第7天显示CRP和PCT水平下降.
- 从术后第3天到第7天,CRP和PCT的下降趋势与显著更高的生存率有关.
- CRP和PCT的增加趋势与短期和长期存活率大幅下降相关.
结论:
- 绝对CRP和PCT水平在LDLT后诊断感染时不可靠.
- 从术后第3天到第7天增加CRP和PCT的趋势是死亡率的重要预测因素.
- 监测生物标志物趋势为LDLT接受者提供了有价值的预后信息.
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