在可切除的胰腺神经内分泌瘤中,淋巴结转移的预测因素:单中心回顾性研究
Xue-Yang Chen1, Jing Du1, Juan-Juan Cai2
1Cancer Center, Department of Gastroenterology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Frontiers in oncology
|February 2, 2026
概括
瘤大小是切除胰腺神经内分泌瘤 (pNENs) 淋巴结转移的主要预测因素. 其他因素,如MLR和血管入侵,也显示出在手术前预测转移的潜力.
科学领域:
- 在瘤学瘤学.
- 手术病理学手术病理学
- 生物标志物 生物标志物
背景情况:
- 胰腺神经内分泌瘤 (pNENs) 呈现出不同的特征.
- 淋巴结转移 (LNM) 显著影响pNEN患者的预后和手术策略.
- 在手术前预测LNM对于指导临床管理至关重要.
研究的目的:
- 确定可切除PNENs的患者中LNM的预测因素.
- 评估单细胞与淋巴细胞比率 (MLR) 作为LNM的潜在预测因子的作用.
- 评估各种因素在预测手术决策LNM方面的临床意义.
主要方法:
- 对64名接受了pNEN切除和淋巴结解剖的患者进行了回顾性分析.
- 使用了单变量和多变量逻辑回归分析.
- 分析了临床数据,炎症标志物 (包括MLR) 和病理特征.
主要成果:
- 15.6%的患者有阳性淋巴结.
- 统一分析确定了血管侵袭,外围神经侵袭,胆红素水平,瘤等级,瘤大小和MLR作为LNM的危险因素.
- 多变量分析显示瘤大小是LNM的唯一独立预测因子.
结论:
- 包括瘤大小,MLR和入侵模式在内的术前因素是LNM在可切除PNEN中的潜在预测因素.
- 多变量分析,特别是ROC分析,提供了更好的预测性能.
- 这些发现可以帮助临床决策制定早期干预和后续策略.
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