术后复发desmoid瘤的危险因素:一个回顾性队列分析
Yue Peng1,2, Shiyao Liu1,2, Yi Li1,2
1Department of Oncology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
Frontiers in oncology
|February 2, 2026
概括
瘤大小和 extremity 位置预测复发的desmoid瘤 (DTs). 更大的瘤和四肢位置表明手术后复发的风险更高,有助于患者的风险评估.
科学领域:
- 在瘤学瘤学.
- 手术病理学手术病理学
- 软组织新生体.
背景情况:
- 德斯莫伊德瘤 (DTs) 是局部侵入性的软组织瘤,复发率很高.
- 由于可变的临床行为和不清楚的复发风险因素,对DTs的最佳管理具有挑战性.
- 确定完全切除后无复发生存 (RFS) 的预测因子对于患者管理至关重要.
研究的目的:
- 在完整的手术切除后,确定患有瘤瘤 (DTs) 的患者无复发生存 (RFS) 的独立预测因子.
- 确定可以帮助术后风险分层和患者咨询的因素.
主要方法:
- 对81名经过切除的desmoid瘤患者的回顾性分析.
- 使用考克斯回归和卡普兰-梅尔分析评估了临床病理变量.
- 采用多变量分析来确定复发的独立预测因素.
主要成果:
- 该队列的5年RFS率为65.5%.
- 单变分析显示了较大的瘤大小,复发性疾病状态和四肢位置作为预后较差的重要预测因素.
- 多变量分析确定了瘤大小 (HR=1.283,p<0.001) 和四肢位置 (HR=2.899,p=0.011) 作为复发的独立风险因素.
结论:
- 瘤大小和四肢位置是完全切除后的desmoid瘤中更糟糕的无复发生存的独立预测因素.
- 这些发现可以帮助术后风险分层为desmoid瘤患者.
- 鉴定的因素可以为患者咨询提供有关预后和管理的信息.
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