肺癌和组织性肺炎的同时发生
Srikanth Vedachalam1, Mohammad Freihat2, Ahmed K Alomari3
1Division of Pulmonary, Critical Care & Sleep Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
组织性肺炎 (OP) 可能与肺癌有关. 显示OP的最小侵入性活检需要高度怀疑恶性瘤,因为7.5%的病例最终被诊断为并发性肺癌.
科学领域:
- 肺部病理学 肺部病理学
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 组织性肺炎 (OP) 通常是良性的,但可以表明潜在的恶性瘤.
- 越来越多地使用微创活检技术,需要了解OP与肺癌的关系.
- 延迟或错过的肺癌诊断是一个风险,当OP没有完全评估.
研究的目的:
- 评估组织性肺炎 (OP) 与肺癌相关的患病率.
- 描述OP和肺癌并存的情况.
- 评估用于检测并发性OP和肺癌的最小侵入性技术的诊断产量.
主要方法:
- 超过8000份肺病理学报告 (2010-2023) 的回顾性审查.
- 确诊的病例与组织病理学诊断的OP与或没有肺癌.
- 利用语言提取来定义两个队列:患有癌症的OP (队列1) 和通过支气管活检的OP (队列2).
主要成果:
- 第1组 (n=57):88%的OP+恶性病例来自手术切除;状细胞癌 (46%) 和腺癌 (37%) 是最常见的. 之前的活检经常错过了OP.
- 队列2 (n=40):通过支气管镜抽样确定OP的患者中有7.5%最终被诊断为肺癌.
- 在第2组中,所有患者都需要重复抽取组织样本以确定癌症诊断.
结论:
- 肺部恶性瘤与组织性肺炎 (OP) 有关.
- 在通过微创方法确定OP时,保持对恶性瘤的高度怀疑指数.
- 如果检测到OP,并怀疑肺癌,就需要立即进一步调查.
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