在中国的艾滋病毒感染者中,共患病的长度演变和风险概况:一项回顾性队列研究
Chenye Liu1, Liqin Sun2, Xi Xiao1
1School of Public Health, Shenzhen University Medical School, Shenzhen, Guangdong, China.
Frontiers in public health
|February 2, 2026
概括
在开始抗逆转录病毒疗法 (ART) 后,艾滋病毒感染者 (PWH) 的多病性迅速增加,这是由像失脂症这样的代谢条件所驱动的. 代谢与传染性多病症的不同风险因素突显了综合护理策略的必要性.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 老年学是一门学科.
背景情况:
- 艾滋病毒感染者 (PWH) 的寿命增加导致多病症的增加,这给健康带来了重大挑战.
- 在PWH开始抗逆转录病毒疗法 (ART) 时,多病症的长期演变尚不清楚.
研究的目的:
- 描述中国PWH共患病的纵向演变.
- 确定代谢性和混合传染性-非传染性多病症的风险概况.
主要方法:
- 对5950名在中国启动ART的PWH进行了回顾性队列研究 (2009-2016年),并进行了长期随访.
- 对26种预定义的并发性疾病进行分析,对多发性疾病及其8年来的演变进行分类.
- 多变量回归模型用于识别特定多病态模式的风险因素.
主要成果:
- 多发病率从ART开始时的25.9%增加到8年后的42.5%,主要是由于无法治愈的疾病.
- 年轻的PWH在无并发症状态下出现了更快的下降,而年长的PWH积累了更多的无法治愈的疾病.
- 失脂症是最常见和最持久的并发症,是大多数群体的核心. 针对代谢性和混合性传染性-非传染性多病症的特定风险因素被确定.
结论:
- 在开始ART后,多种疾病,特别是像失脂症这样的代谢状况,在中国PWH中迅速增加.
- 不同的风险概况需要将心脏代谢查,感染控制和主动性失脂症管理纳入艾滋病毒治疗.
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