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细菌直肠殖民模式在儿科患者中的患病率和特征:一个横截面研究
Aynaa Al-Khatib1, Amal Naous2, Elie Salem Sokhn1
1Molecular Testing Laboratory, Medical Laboratory Department, Faculty of Health Sciences, Beirut Arab University, Beirut, Lebanon.
New microbes and new infections
|February 2, 2026
概括
儿科直肠感染多药耐药生物体,特别是产生ESBL的大肠杆菌,是常见的. 之前使用抗酸药与耐药性有关,这表明需要进一步的儿科监测和仔细的抗生素评估.
科学领域:
- 微生物学 微生物学
- 公共卫生 公共卫生
- 儿科 儿科 儿科
背景情况:
- 抗菌素耐药性 (AMR) 是一个重大的全球健康威胁.
- 对抗药物耐药性的监测对于了解其流行率和导致因素至关重要.
- 儿童细菌分离物需要对耐药性模式和相关临床数据进行评估.
研究的目的:
- 评估来自儿科患者的细菌分离物的分布和耐药机制.
- 确定与儿童抗菌素耐药性相关的人口和临床因素.
- 研究ESBL,AmpC,CRE和MRSA等特定耐药性机制的流行情况.
主要方法:
- 从贝鲁特的儿科患者收集了直肠拭子.
- 使用标准培养和生化技术进行细菌鉴定.
- 使用抗微生物敏感性测试和聚合酶链反应 (PCR) 来描述耐药性基因和机制.
- 统计分析 (基平方或费舍尔精确测试) 评估了电阻和样本特征之间的关联.
主要成果:
- 在118个直肠隔离物中,大肠杆菌占主导地位 (75.4%).
- 31.36%的分离物表现出主要的耐药性机制 (ESBL,AmpC,CRE或MRSA).
- 产生ESBL的大肠杆菌 (22%) 与blaCTX-M是最常见的;之前服用抗酸药物与耐药性有显著的关联 (p=0.03).
结论:
- 儿科群体中经常出现多药耐药生物的直肠殖民,主要是由ESBL产生的大肠杆菌驱动的.
- 虽然AMpC,CRE和MRSA不太常见,但它们代表了关键的抵抗机制.
- 耐药性和抗酸使用之间的联系强调需要广泛的儿科监测和明智的抗生素和抗酸使用.
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