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基于纳米材料的光学生物传感器及其生物医学和生物制药应用的最新进展

Mengjia Xu^1,2, Lutfun Nahar³, Kenneth J Ritchie⁴

¹Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Zhejiang International Cooperation Base of Biomedical Materials Technology and Application, Ningbo Cixi Institute of Biomedical Engineering, Laboratory of Advanced Theranostic Materials and Technology, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, Zhejiang, 315201, China.

Journal of pharmaceutical analysis

|February 2, 2026

概括

通过功能化纳米材料增强的光学生物传感器,提供便携式和快速的分子监测. 本综述探讨了它们的机制和优势,用于先进的诊断和生物制药应用.

科学领域:

纳米材料科学科学纳米材料科学
生物医学工程生物医学工程
分析化学分析化学

背景情况:

光学生物传感器由于便携性,小型化和快速响应而越来越受欢迎.
它们的应用范围包括家庭诊断,药理学和持续分子监测.
功能化的低维纳米材料 (0D,1D,2D,3D) 是推动光学生物传感器设计的关键.

研究的目的:

审查光学生物传感的基本机制.
在光学生物传感器中展示低维纳米材料的优势.
突出生物医学和生物制药领域生物传感策略的未来方向.

主要方法:

关键的光学生物传感机制的总结:局部表面等离子体共振 (LSPR),光发光 (PL),表面增强拉曼散射 (SERS),基于纳米酶的色度策略,化学发光,生物发光和电化学发光.
审查各种低维纳米材料 (0D,1D,2D,3D) 的优势.
对不同类型的光学生物传感器纳米材料适用性的比较分析.

主要成果:

详细介绍了像LSPR,PL和SERS这样的光学生物传感机制.
低维纳米材料在有针对性的生物传感方面具有显著的优势.
特定的纳米材料在不同的生物传感应用中显示出优越性.

结论:

与低维纳米材料集成的光学生物传感器提供了卓越的性能.
进一步开发对于推动生物医学研究和生物制药应用至关重要.
推广这些技术将确定生物传感的未来方向.

关键词:

在家诊断在家诊断生物制药领域的应用.持续的分子监测持续的分子监测生物感应的基本机制低维纳米材料是一种低维纳米材料.有光学生物传感器.

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