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CXCL8/SDC1轴调解瘤干细胞相互作用,以驱动甲状腺癌的远程转移

Wenjuan Wang¹, Jian Zhou², Baorui Tao²

¹Department of Pathology, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Journal of pharmaceutical analysis

|February 2, 2026

概括

研究人员确定CXCL8 / SDC1轴对甲状腺癌 (THCA) 转移至关重要. 单细胞和瘤干细胞之间的这种相互作用激活了JAK-STAT信号,推动了癌症的进展,并表明THCA患者的预后不佳.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
免疫学免疫学免疫学

背景情况:

甲状腺癌 (THCA) 转移仍然是一个重大挑战.
了解THCA远程传输的分子驱动因素对于改善患者的治疗结果至关重要.

研究的目的:

阐明THCA远程传输背后的分子机制.
为了研究C-X-C动机化学因配体8 (CXCL8) 阳性单细胞和syndecan-1 (SDC1) 阳性瘤干细胞之间的相互作用.

主要方法:

单细胞和THCA患者样本的空间转录组测序.
使用Seurat,CellChat和SPOTlight R软件包进行生物信息分析.
在小鼠体外共培系统,ELISA,西式涂抹和体内异种/转移模型.

主要成果:

鉴定出CXCL8/SDC1轴是Janus酶信号转换器和转录激活器 (JAK-STAT) 信号传输的关键调解器.
这个轴促进THCA干细胞的自我更新,入侵和转移.
高CXCL8/SDC1表达与高风险C1亚型相关,THCA患者的预后较差.

结论:

CXCL8阳性单细胞和SDC1阳性瘤干细胞的相互作用激活了JAK-STAT通路,促进了THCA转移.
针对CXCL8/SDC1轴为THCA提供了一个潜在的治疗策略.
这个轴是预测THCA患者预后的有希望的生物标志物.

关键词:

在CXCL8中,CXCL8是CXCL8.蜂通讯蜂通讯是通过蜂通讯进行的.单细胞转录基因组测序空间转录基因组序列的测序辛德肯-1是什么意思?甲状腺癌是什么?甲状腺癌是什么?瘤的分类瘤的分类瘤的远程传输是可以实现的.

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