雄激素受体对三阴性乳腺癌的影响:系统性审查和元分析研究
Shalini Hassan Doreswamy1, Ramesh B V Nimmagadda2, SubbaRao V Madhunapantula1
1Centre for Excellence in Molecular Biology and Regenerative Medicine, Department of Biochemistry, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
BMJ public health
|February 2, 2026
概括
在三阴性乳腺癌 (TNBC) 中,雄激素受体 (AR) 表达可能会改善短期无疾病生存率 (DFS),但不是整体生存率 (OS). 对于在TNBC患者中进行标准化的AR评估,需要进一步的研究.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 生物标志物 生物标志物
背景情况:
- 三阴性乳腺癌 (TNBC) 缺乏向疗法,因此需要确定预后标志物.
- 雄激素受体 (AR) 蛋白表达是TNBC的一个潜在生物标志物.
- 在TNBC中AR的预后影响需要进一步澄清.
研究的目的:
- 评估AR蛋白表达对TNBC患者无病生存期 (DFS) 和整体生存期 (OS) 的预后意义.
- 通过系统审查和元分析来综合现有证据.
主要方法:
- 2000年1月至2024年11月期间发表的研究的系统审查和元分析.
- 包括研究报告AR蛋白表达通过免疫组织化学在女性TNBC患者.
- 对多变量危险比率 (HRs) 进行分析,用于DFS和OS的95%置信区间 (CI).
主要成果:
- 包括11项与4446名患者的研究;28.4%显示AR阳性.
- AR阳性表明了改善DFS (HR 0.67) 和OS (HR 0.76) 的趋势,尽管在统计学上并不显著.
- 在短期随访 (≤5年) 和中高收入国家研究中观察到显著的DFS益处.
- 抗胰岛素切断值 (≥5%) 是异质性的显著调节者 (HR 0.33).
结论:
- 在TNBC中AR表达可能与短期的DFS益处有关,但没有改善OS或长期结果.
- AR状态可能具有临床价值,特别是在特定的子组中.
- 标准化AR评估方法有必要在TNBC进行进一步调查.
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