甲基马龙酸的升高,但不是维生素B12,预测高脂成年人全因死亡率:一项前性队列研究
Qingtao Gong1, Baiqiang Wang1, Leiyang Li1
1Public Health Clinical Center Affiliated to Shandong University, Shandong University, Jinan, China.
Frontiers in nutrition
|February 2, 2026
概括
甲基马龙酸 (MMA) 和功能性维生素B12缺乏症的升高增加了高脂血症患者的死亡风险. 仅仅血清维生素B12水平并不能预测风险,这表明MMA是一个关键的生物标志物.
科学领域:
- 生物化学 生物化学
- 临床医学 临床医学
- 营养科学 营养科学
背景情况:
- 患有高脂血症的患者面临显著的残留风险,尽管使用降脂疗法.
- 了解导致这一群体死亡的因素对于改善患者的治疗结果至关重要.
研究的目的:
- 调查血清甲基马龙酸 (MMA),维生素B12和功能维生素B12状态与高脂血症个体因任何原因死亡的独立和联合关联.
主要方法:
- 国家健康和营养检查调查 (NHANES) 对超脂血症参与者的数据 (2011-2014) 的分析.
- 利用加权的Cox比例危险模型来评估MMA,维生素B12和死亡率之间的关系.
- 通过使用受限立方线和定义功能维生素B12缺乏症,通过高MMA与正常/高B12水平检查了非线性关联.
主要成果:
- 较高的血清MMA水平与增加的全因死亡风险显著相关 (调整后HR=1.55).
- 功能性维生素B12缺乏表明死亡风险最高 (调整HR=2.40).
- 仅仅血清维生素B12水平就没有显示出与死亡率有显著的独立关联.
结论:
- 血清MMA升高和功能性维生素B12缺乏是高脂血症所有原因死亡率的显著预测因素.
- 在这种患者群体中,MMA可以作为评估死亡风险的新生物标志物.
- 评估功能性维生素B12状态对于治疗高脂血症具有临床重要性.
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