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Infection01:20

Infection

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
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Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

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Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
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Stages of Infection01:26

Stages of Infection

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Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
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Overview
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Defense Mechanism Against Infection01:26

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Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
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Sexually Transmitted Infections01:26

Sexually Transmitted Infections

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Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
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相关实验视频

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Biology of Microbial Communities - Interview
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在社区获得的肺空间感染中检测微生物使用BioFire联合感染面板和个人PCR检测.

Portia Mira1, Ruben Dyrhovden2, Marit Gjerde Tellevik2

  • 1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
|February 2, 2026
PubMed
概括

分子诊断,包括BIOFIRE联合感染小组,与传统培养方法相比,可以更好地检测社区获得的肺部感染. 这种方法增强了微生物分析,以获得更好的治疗策略.

关键词:
恩皮埃马 (Empyema) 是一种病.肺腔感染 肺腔感染快速分子诊断技术 快速分子诊断技术

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科学领域:

  • 医学微生物学 医学微生物学
  • 传染性疾病 传染性疾病
  • 分子诊断学 分子诊断学

背景情况:

  • 社区获得性肺部感染的诊断依赖于及时和准确的微生物识别.
  • 目前的诊断方法,包括培养,往往缺乏有效管理所需的速度和灵敏度.
  • 分子诊断方法有望改善在多液中的病原体检测.

研究的目的:

  • 系统地比较分子诊断方法来检测肺部感染中的病原体.
  • 评估BIOFIRE关节感染 (JI) 面板在标签之外的用途,用于肺部液体分析.
  • 评估补充内部PCR的有用性,以提高BIOFIRE JI小组的绩效.

主要方法:

  • 在两个国际医疗中心分析了来自162名患者的多液样本.
  • 性能比较包括BIOFIRE JI小组 (带有和没有内部PCR),16S核糖体RNA基因PCR/测序和常规培养.
  • 公司内部的PCR针对特定的病原体:Fusobacterium nucleatum群,Streptococcus intermedius/constellatus,以及Aggregatibacter aphrophilus.这些病原体是目标.

主要成果:

  • 在BIOFIRE JI小组中,加上三项内部PCR检测,检测到96.8%的肺部感染,在70.8%的病例中实现了完整的微生物概况.
  • 16S rRNA基因PCR/测序表明检测率为92.2%,完整配置文件为87.0%.
  • 传统培养只在31.9%的肺部液体中发现了细菌,而在15.3%的肺部液体中发现了完整的细菌样本.

结论:

  • 分子方法,特别是基于面板的PCR诊断,对于诊断腔空间感染至关重要.
  • 虽然BIOFIRE JI面板是为突液设计的,但它显示出修改和用于肺部液体诊断的巨大潜力.
  • 这些发现支持开发快速,可访问的分子诊断,以简化肺部感染的治疗.