在抑郁症患者中,双极风险的规范性大脑变异性,临床维度和分子转录组相关性
Junneng Shao1,2,3, Ting Wang1,2, Wei Zhang1,2
1School of Biological Sciences & Medical Engineering, Southeast University, Nanjing, China.
Psychiatry and clinical neurosciences
|February 2, 2026
概括
神经成像揭示了明确的大脑模式,使双相情感障碍 (BD) 与主要抑郁障碍 (MDD) 区分开来. 这些发现有助于识别早期的BD,并为情绪状态过渡提供有针对性的干预措施.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 双极性障碍 (BD) 经常被误诊为主要抑郁障碍 (MDD),因为抑郁症状通常出现在躁狂发作之前.
- 抑郁症患者情绪状态转变的神经生物学基础尚未得到充分理解.
研究的目的:
- 探索患有严重抑郁症 (MDD) 和双相情感障碍 (BD) 的患者情绪状态转变的神经生物学机制.
- 为了识别不同的神经成像模式,可以区分MDD和早期BD.
主要方法:
- 一个规范寿命模型被用来分析389名抑郁症患者 (MDD,BD和过渡到BD[tBD]) 的大脑结构和功能变化.
- 一个维度方法确定了临床风险因素和大脑变异性之间的跨诊断共变模式.
- 患者的随访时间为6-13年.
主要成果:
- 确定了两种共变模式:模式1区分了BD与MDD,基于边缘/亚皮层和注意力/执行网络的活性变化.
- 模式2通过在默认模式,边缘和皮层下网络中显示灰色质缩来识别从MDD向BD (tBD) 的过渡.
- 基因分析将DRD2相关的多巴胺风险与模式2中奖励回路中的结构性缺陷联系起来.
结论:
- 这项研究提供了关于情绪状态过渡和早期BD中微妙的症状变化的神经生物学基础的见解.
- 这些发现为BD患者的早期干预提供了潜在的目标,这些患者尚未经历过躁狂/低躁狂.
相关概念视频
Correlations
35.9K
Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
35.9K
Correlation and Causation
42.7K
Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
42.7K
Long-term Depression
33.3K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.3K
Bipolar Disorder
754
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
754
Freezing Point Depression and Boiling Point Elevation
40.1K
Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
40.1K
Depressants
436
Depressant drugs, including alcohol and sedative-hypnotics, diminish central nervous system activity by enhancing the action of gamma-aminobutyric acid (GABA), a neurotransmitter that reduces brain activity and promotes relaxation. These substances can have various therapeutic uses but also pose significant risks, especially when misused or combined.
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
436


