用VMAT2抑制剂治疗晚期运动障碍的使用
Orges Alabaku1,2, Mark Olfson3,4, T Scott Stroup3
1Rutgers University Center for Pharmacoepidemiology and Treatment Science, New Brunswick.
Journal of clinical psychopharmacology
|February 2, 2026
概括
晚期动力障碍 (TD) 诊断和使用囊泡单胺转运体2抑制剂 (VMAT2-Is) 的治疗从2017年增加到2022年. 然而,TD的诊断仍然不足,这表明需要更好地识别和访问VMAT2-Is.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 迟性运动障碍 (TD) 是一种运动障碍,通常与抗精神病药物使用有关.
- 膀单胺转运体2抑制剂 (VMAT2-Is) 是FDA批准的TD治疗方法,但它们的利用模式尚未得到充分记录.
研究的目的:
- 描述TD诊断和VMAT2-I在使用抗精神病药物治疗的精神健康状况的成年人中的使用趋势.
- 在这个人群中确定VMAT2-I使用的预测因素.
主要方法:
- 对2017-2022年MarketScan数据的分析,针对18-65岁的成年人.
- 通过ICD-10代码识别TD和心理健康诊断.
- 根据处方要求确定VMAT2-I使用情况;用于评估预测因素的后勤回归.
主要成果:
- 在2017年至2022年期间,TD诊断从0.45%增加到0.57%,VMAT2-I使用从0.05%增加到0.22%.
- 预测VMAT2-I使用的预测因素包括第一代抗精神病药物的使用,精神分裂症,双相情感障碍,女性性别和年龄较大.
- 在TD患者中,精神分裂症,双相情感障碍和老年预测VMAT2-I使用.
结论:
- TD诊断和VMAT2-I治疗率呈现上升趋势,但仍然很低.
- 这些发现强调了需要改进TD识别和加强符合条件的患者对VMAT2-Is的访问.
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