响应性神经刺激导致向内部位的内高频振荡发作模式与更好的2年控制结果有关
Doris Deng1, Brian Jung1, Lilit Mnatsakanyan1
1Department of Neurology, University of California, Irvine, Irvine, California, USA.
Epilepsia
|February 2, 2026
概括
高频振荡 (HFOs) 改善了响应神经刺激 (RNS) 手术中的发作局部化. 在发作发作区 (SOZ) 准HFO显著提高了患者的发作减少.
科学领域:
- 神经学 神经学
- 神经外科 神经外科
- 发病学 (Epileptology) 是一个专业的学科.
背景情况:
- 耐火性焦点发作的往往需要响应神经刺激 (RNS) 来治疗.
- 内脑电图 (IEEG) 对于识别发作发作区 (SOZ) 至关重要,但其成功率可变.
- 高频振荡 (HFOs) 是已知的开始特征.
研究的目的:
- 研究ictal HFO作为优化RNS准的标记物的实用性.
- 为了确定是否针对由HFO确定的SOZ改善了扣押控制结果.
主要方法:
- 在2015-2022年间接受IEEG和RNS植入的患者被追溯分析.
- 对IEEG数据进行了审查,以检测ictal HFO发病模式.
- RNS的领先位置与SOZ和2年控制结果相关.
主要成果:
- 在33名符合条件的患者中,25人被纳入最终分析.
- 大约78.8%的人实现了≥50%的发作减少,21.2%的人无发作.
- 发现针对SOZ与ictal HFO和改善控制之间存在显著的关联 (p=0.0078),特别是在超级响应者中.
结论:
- Ictal HFOs为发性组织提供了增强的局部化价值.
- 在SOZ中精确地定位HFO对于成功的RNS结果至关重要.
- 与传统的位定位方法相比,这种方法可能会提高RNS的疗效.
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