椎间盘出血与初级开放角玻璃眼进展之间的纵向关联:系统性审查和元分析
Chelsea Qiu Lin Tan1, Claire Jing-Wen Tan1, Bee Choo Tai2
1Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore.
Ophthalmic epidemiology
|February 2, 2026
概括
光盘出血 (DH) 预测初级开角玻璃眼 (POAG) 的进展,特别是在正常张力玻璃眼 (NTG). 基线DH表明视野损失和神经纤维层稀薄的风险更高.
科学领域:
- 眼科医生 眼科 眼科
- 玻璃眼研究研究 玻璃眼研究
- 医学诊断 医学诊断 医学诊断
背景情况:
- 光盘出血 (DH) 是初级开角青光眼 (POAG) 的关键指标.
- 初始的DH对POAG和正常张力格拉瘤 (NTG) 进展的影响缺乏广泛的纵向数据.
- 了解DH的作用对于预测青光眼恶化至关重要.
研究的目的:
- 系统地审查和元分析基线DH和POAG/NTG进展之间的关联.
- 为了确定初始的DH是否会影响青光眼恶化的速度.
- 为了研究DH位置和视野恶化之间的联系.
主要方法:
- 观察性研究的系统审查和元分析 (PROSPERO CRD42021292572).
- 在PubMed,Embase,Cochrane,SCOPUS和科学网上搜索到2025年7月1日.
- 包括18岁以上患者的研究,具有定义的POAG/NTG进展标准.
主要成果:
- 包括22项研究 (7项前性,15项后性).
- 基线DH与POAG进展 (OR=4.51) 和NTG进展 (OR=5.15) 显著相关.
- DH通常发生在时间下,与视野缺陷位置相关联.
结论:
- 基线DH是POAG进展的显著预测因素,特别是在NTG.
- 患有POAG和基线DH的患者需要加强对视网膜神经纤维层稀薄和视野损失的监测.
- 缺血病的存在需要在绿眼病管理中进行更密切的临床监测.
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