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Updated: Feb 4, 2026

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评估古代DNA采样策略用于人类自然选择的推理,使用等位基因频率时间序列数据

Lucas Anchieri1,2, Carlos Eduardo G Amorim3, Samuel Neuenschwander1,4

  • 1Department of Computational Biology, University of Lausanne, Lausanne 1015, Switzerland.

Genome biology and evolution
|February 2, 2026
PubMed
概括

在古代人类DNA (aDNA) 中检测自然选择是可行的,尽管数据稀疏,但强选择 (s ≥0.02) 和~100个样本是可行的. ApproxWF表现最好,虚假阳性很低,用于强大的选择推理的功率很高.

关键词:
一个DNADNA的DNA古遗传学是一种古遗传学.人口遗传学 人口遗传学选择的选择选择的选择.模拟器模拟器模拟器模拟器时间序列时间序列

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