在人类肠道微生物群中停留轨迹的宏观生态动态
William R Shoemaker1, Jacopo Grilli1
1Quantitative Life Sciences, The Abdus Salam International Centre for Theoretical Physics (ICTP), Trieste, Italy.
mSystems
|February 2, 2026
概括
人体肠道微生物群的波动,称为逗留轨迹,以其持续时间和形状为特征. 它们的典型时间表与环境噪音有关,而不是意味着丰富,为微生物社区动态提供了洞察力.
科学领域:
- 微生物生态学 微生物生态学
- 系统生物学 系统生物学
- 数学生物学 数学生物学
背景情况:
- 人的肠道微生物群是一个复杂的生态系统,微生物丰富度因饮食等宿主行为而波动.
- 尽管环境变化,肠道微生物群体表现出弹性,倾向于随着时间的推移恢复到稳定状态的丰度.
- 这些与稳定状态的暂时偏差被称为逗留轨迹,对于理解微生物组动态至关重要.
研究的目的:
- 系统地描述人类肠道微生物组中逗留轨迹的宏观生态.
- 分析这些微生物波动的持续时间,形状和社区间的动态.
- 使用随机逻辑模型解释经验观测.
主要方法:
- 利用随机步行研究的理论工具来分析逗留轨迹.
- 经验性地描述逗留轨迹的长度,长度-高度关系和偏差.
- 应用随机物流模型来解释生态动态.
主要成果:
- 逗留轨迹的典型时间尺度独立于微生物成员的平均丰度 (承载能力).
- 时间表与变化系数有很强的相关性,反映了环境噪音.
- 确定了对各种微生物群落的动态,时间尺度和波动的基本见解.
结论:
- 住宿轨迹特征提供了对肠道微生物组动态的基本见解.
- 随机物流模型有效地解释和统一了微生物丰度波动中观察到的模式.
- 这项研究加深了我们对人类肠道微生物社区弹性和稳定性的理解.
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