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与分析证实暴露于MDMB-4en-PINACAA相关的临床特征和社会人口统计特征
Emma Jayne Moyns1, Lauren Starbrook2, Mark Pucci1,2
1National Poisons Information Service, Birmingham Unit, City Health Campus, Birmingham, UK.
Clinical toxicology (Philadelphia, Pa.)
|February 2, 2026
概括
强大的合成大麻素MDMB-4en-PINACA经常被伯明翰的无家可归者使用. 这种药物引起严重的毒性,包括意识丧失和发作,突出显著的公共卫生问题.
科学领域:
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
- 紧急医疗 紧急医疗
背景情况:
- 合成大麻素受体激动剂MDMB-4en-PINACA自2017年以来一直在娱乐药物市场上销售.
- 它的使用在脆弱和贫困人口中尤为普遍,包括那些经历无家可归的人.
研究的目的:
- 调查MDMB-4en-PINACA暴露在急性药物毒性患者中的临床特征和患病率.
- 了解受这种合成大麻素影响的个体在城市急诊室环境中的特征.
主要方法:
- 进行了一系列回顾性观察案例.
- 从2020年11月至2024年12月期间,从英国伯明翰急诊室的患者收集了数据.
- 毒理学查确定了暴露于MDMB-4en-PINACA的患者.
主要成果:
- 分析了202例涉及163名暴露于MDMB-4en-PINACA的患者的医院病例.
- 大多数受影响的患者是男性 (82.6%),平均年龄为39岁; 32.2%是无家可归者.
- 常见的临床特征包括意识减弱 (81.2%),激动 (49%),发作 (30.2%) 和低血压 (22.3%). 记录了四起死亡事件.
结论:
- 在伯明翰的男性无家可归人口中,MDMB-4en-PINACA的使用是常见的和持久的.
- 临床效应严重且与强烈的合成大麻素毒性一致,通常因多种药物使用而加剧.
- 合成大麻素受体激动剂的低成本和高强度可能有助于它们在无家可归者中受欢迎.
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