与工作相关的噪音暴露与认知表现的关联:PS-1 rs16593232的效果修改
Lei Huang1, Jing Zhang2, Shushan Zhang3
1Department of Postgraduate Students, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China.
Journal of Alzheimer's disease : JAD
|February 2, 2026
概括
职业噪音暴露和一个特定的基因变异 (PS-1 rs165932T) 与工人的认知表现下降有关. 减轻噪声风险对于保护认知健康至关重要.
科学领域:
- 神经科学是一个神经科学.
- 环境健康 环境健康
- 遗传学 是一个遗传学.
背景情况:
- 在年轻人中,认知障碍正在增加.
- 环境噪音和遗传因素对痴呆风险的综合影响尚不清楚.
- 这项研究探讨了职业噪音和遗传倾向对认知功能的协同效应.
研究的目的:
- 调查与工作相关的累积噪声暴露 (WCNE) 和遗传多态性 (APOE,PS-1) 与较低的认知表现 (LCP) 之间的关联.
- 分析WCNE,遗传因素和认知结果之间的潜在相互作用.
主要方法:
- 研究了中国西部523名工人的队列.
- 对每个参与者进行了与工作相关的累积噪声暴露 (WCNE) 评估.
- 进行了APOE (rs429358/rs7412) 和PS-1 (rs165932) 多态的基因定型,并使用MMSE和MoCA评估认知功能.
主要成果:
- APOE多态性与LCP没有显著的关联.
- PS-1 rs165932T等位基因 (PS-1T) 与LCP显著相关 (p < 0.05).
- 年龄和WCNE对LCP有显著的相互作用,而PS-1T改变了WCNE和LCP之间的关系.
结论:
- 调查结果强调了减少职业噪音暴露的必要性,特别是在潜在的脆弱人群中.
- 这项研究提供了证据,支持进一步研究将噪音,衰老和遗传敏感性与认知障碍联系在一起的生物机制.
相关概念视频
Piaget's Stage 1 of Cognitive Development
1.7K
The sensorimotor stage, the initial phase of Jean Piaget's theory of cognitive development, spans the first two years of a child's life. During this period, infants actively engage with their surroundings, building cognitive awareness through direct interaction with the world. This interaction is primarily based on sensory perception and motor actions, allowing infants to gradually understand basic physical properties and predict how objects interact within their environment.
Exploration...
Exploration...
1.7K
Histone Modification
16.1K
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...
16.1K
Histone Modification
4.5K
4.5K
Cognitive Dissonance
37.5K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
37.5K
Spreading of Chromatin Modifications
9.5K
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
Writers
The writer...
9.5K
Association Areas of the Cortex
9.4K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
9.4K


