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Updated: Feb 4, 2026

A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells
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内源性CD28驱动了骨髓瘤和淋巴瘤模型中CAR-T细胞的持续活动

Mackenzie M Lieberman1, Jason H Tong2, Nkechi U Odukwe3

  • 1Roswell Park Cancer Institute Buffalo, NY United States.

Blood cancer discovery
|February 2, 2026
PubMed
概括

在用CAR T细胞治疗的多发性骨髓瘤和淋巴瘤模型中,阻断CD28信号意外加速瘤再生. 在CAR T细胞上的内源性CD28对持续的抗瘤活性和瘤微环境中的细胞因子释放至关重要.

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