不同的Ki-67截止值的预后意义 定义的光线B HER2-阴性乳腺癌
Xin Ye1,2,3, Xiaoyun Zhou1,2,3, Qi He1,2,3
1The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Cancer investigation
|February 2, 2026
概括
由ER/PR阳性和HER2阴性状态定义的光线B (HER2-) 乳腺癌,预后不佳. 20%的Ki-67切割值有效地区分了可操作病例的预后差异.
科学领域:
- 在瘤学瘤学.
- 乳腺癌研究研究 乳腺癌研究
- 癌症生物标志物 癌症生物标志物
背景情况:
- 光线B (HER2-) 乳腺癌的特点是ER/PR-阳性和HER2-阴性,通常具有高的Ki-67指数,表明预后更差.
- 在这种亚型的中国患者中预后的最佳Ki-67切割值尚不清楚.
研究的目的:
- 为了研究Ki-67表达在Luminal B (HER2-) 可手术乳腺癌的预后意义,在一个中国队列.
- 为了确定一个优化的Ki-67切割值来区分预后差异.
主要方法:
- 对4940名ER或PR阳性和HER2阴性可手术乳腺癌患者的回顾性分析.
- 评估不同Ki-67截止值 (14%, 20%, 30%) 的无疾病生存率 (DFS),整体生存率 (OS),远程转移无生存率 (DMFS) 和乳腺癌特定生存率 (BCSS).
主要成果:
- 光线B (HER2-) 瘤表现出不良的DFS,无论使用的Ki-67切断线如何.
- 光线B (HER2-) 亚型,具体定义为PR ≤20%和高Ki-67指数,与较低的OS,DMFS和BCSS有关.
- 20%的Ki-67切割值被发现是区分预后结果的最佳值.
结论:
- 基-67表达是Luminal B (HER2-) 可手术乳腺癌的显著预后因素.
- 20%的Ki-67切割值为中国的这种患者群体提供了优化的预后分层.
- 这些发现可以帮助改进治疗策略和患者管理.
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