一个以小组为基础的干预措施的影响,以缓解同时进行化疗和放射治疗诱导的缺食症:一项回顾性队列研究
Cindy Levesque-Boissonneault1, Nancy Latulippe2, Édith Filion3
1Université du Québec à Trois-Rivières, 3351, boulevard des Forges, Trois-Rivières, Québec, Canada. cindy.levesque-boissonneault@uqtr.ca.
Dysphagia
|February 2, 2026
概括
基于小组的吞疗法显著降低了同时接受化学放射治疗 (CCRT) 的头癌患者的消化不良毒性. 这种干预措施改善了治疗的出席率,并减少了与个人治疗相比使用食管的需求.
科学领域:
- 在瘤学瘤学.
- 语音语言病理学 语言病理学
- 康复医学 康复医学 康复医学
背景情况:
- 口腔喉功能障碍是头癌 (HNC) 同步化疗放射治疗 (CCRT) 的常见和严重副作用.
- 预防性吞干预措施,包括CCRT期间的炼计划,用于减轻吞障碍.
- 患者持续坚持治疗仍然是一个挑战,可能会限制干预的有效性.
研究的目的:
- 为了比较基于小组的预防性吞干预 (GB-PSI) 与个人预防性吞干预 (I-PSI) 在接受CCRT的HNC患者中的有效性.
- 评估对吞相关结果,治疗出席率和与健康相关的生活质量 (HRQOL) 的影响.
主要方法:
- 追溯队列研究分析了188名HNC患者的数据 (I-PSI: n=101; GB-PSI: n=87).
- 贝叶斯回归模型被用来比较两个干预组之间的吞结果,治疗出席率和HRQOL.
- 结果包括鼻胃管的放置,消化不良毒性等级和治疗会话的出席率.
主要成果:
- 与I-PSI队列相比,GB-PSI队列需要鼻胃管的可能性显著降低.
- 在GB-PSI组的患者在CCRT期间和之后经历了显著较低的失症毒性等级.
- 在CCRT期间,GB-PSI参与者参加了更多的治疗课程,并在治疗后需要更少的会议.
结论:
- 基于小组的预防性吞干预似乎对接受CCRT的HNC患者有益.
- GB-PSI可能会改善治疗的坚持性,并降低食障碍的严重程度.
- 需要进一步的前性研究来证实这些发现并探索更广泛的影响.
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