早期Ga-FAPI-46 PET/CT基于体积的参数在系统性硬化症相关的间歇性肺病中的探索性评估
Sarah Beishan Tai1,2, Wei Ming Chua1,2,3, Cherie Wei Qi Ng1
1Department of Nuclear Medicine and Molecular Imaging, Singapore General Hospital, 16 College Road, Block 2 Basement 1, Singapore, 169854, Singapore.
European journal of nuclear medicine and molecular imaging
|February 2, 2026
概括
早期的68Ga-FAPI-46 PET/CT成像参数在识别渐进性系统性硬化症相关的间歇性肺病 (SSc-ILD) 中显示出前途. 这些早期基于体积的PET发现与疾病进展相关,有助于对SSc-ILD患者及时进行干预.
科学领域:
- 放射学 放射学是一门学科.
- 核医学就是核医学.
- 肺部医学 肺部医学
背景情况:
- 系统性硬化症相关的间歇性肺病 (SSc-ILD) 是系统性硬化症 (SSc) 的严重并发症,其特征是渐进性纤维化和炎症.
- 目前的诊断工具难以区分渐进性和非渐进性SSc-ILD,阻碍了早期治疗干预.
- 68Ga-FAPI-46是一种正电子发射断层扫描 (PET) 追踪器,准纤维细胞激活蛋白α (FAP),这是激活纤维细胞的标记物,在纤维炎症疾病中具有很高的亲和力和保留力.
研究的目的:
- 调查早期与晚期68Ga-FAPI-46 PET/CT成像参数在评估SSc-ILD.的有用性.
- 为了确定纤维炎性肺病中68Ga-FAPI-46 PET/CT的最佳成像时间点和PET参数.
主要方法:
- 通过INBUILD试验标准定义的渐进性 (n=8) 和非渐进性 (n=14) SSc-ILD组之间的早期 (10分钟) 和晚期 (60分钟) 68Ga-FAPI-46 PET参数的比较.
- 对PET参数与肺功能测试 (PFT) 和高分辨率计算机断层扫描 (HRCT) 参数的相关性分析.
- 确定PET参数的最佳值,使用最接近{0,1}的标准.
主要成果:
- 早期总损伤FAPI吸收 (TL-FAPI10min) 和受影响的肺体积 (AV10min) 在进展性SSc-ILD患者中明显高于非进展者 (p=0.020和p=0.042,分别).
- 早期PET参数与PFT和定量HRCT参数的相关性比晚期PET参数更强大和更一致.
- 基于体积的PET参数与基于强度的参数相比,与PFT和HRCT的相关性更为一致,TL-FAPI10分钟值为928显示出最佳诊断性能 (AUC0.80).
结论:
- 早期基于体积的68Ga-FAPI-46 PET/CT参数与SSc-ILD近期的疾病进展有关.
- 需要在治疗反应研究中进行前性验证,以确认这些PET参数的临床实用性及其在SSc-ILD管理中的初步值.
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