免疫调节效应和肠道微生物群的调节 酒酵母曼纳提德 在循环胺诱导的免疫抑制小鼠
Shuang Zhao1, Haidi Wang1, Shuo Zhao1
1College of Life Sciences , Qingdao University , Qingdao, 266071, China.
Archives of microbiology
|February 2, 2026
概括
来自酒酵母的曼纳提德 (MTE) 增强了免疫功能和肠道健康. 这种酵母衍生的化合物显示出作为健康和免疫抑制个体的食补充剂的潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 酵母是食品生产 (造,烤) 的组成部分.
- 酒酵母含有具有潜在健康益处的生物活性化合物.
- 了解酵母衍生化合物的免疫调节作用对于健康应用至关重要.
研究的目的:
- 研究来自酒酵母的曼纳提德 (MTE) 的免疫调节和益生菌潜力.
- 为了评估MTE对循环胺 (CTX) 诱导的免疫抑制小鼠的影响.
- 评估MTE对健康和免疫抑制小鼠肠道微生物群和免疫参数的影响.
主要方法:
- 将MTE给CTX诱导的免疫抑制小鼠和未经治疗的小鼠.
- 评估体重,器官形态和免疫细胞因子 (TNF-α,IFN-γ).
- 肠道微生物组合的分析和紧密结合蛋白的表达 (Occludin,E-cadherin,ZO-1).
主要成果:
- MTE缓解了免疫抑制引起的体重减轻和恢复器官形态.
- 在免疫抑制小鼠中,MTE增加了关键免疫细胞因子 (TNF-α,IFN-γ).
- MTE使肠道微生物群正常化,丰富了有益细菌,并提高了紧密结合蛋白的调节.
结论:
- 在免疫抑制小鼠中,MTE显示出显著的免疫调节作用.
- 在健康和免疫抑制状态下,MTE充当益生菌,促进有益的肠道细菌.
- 作为增强免疫健康和肠道功能的食补充剂,MTE显示出前景.
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