烟草吸烟与原发性开角玻璃眼无关:一个系统性审查和元分析
Saajan Ramji1, Sohail Daniel2, Abdus Samad Ansari3,4
1North West London NHS Foundation Trust, London, UK.
International ophthalmology
|February 2, 2026
概括
这项研究发现,烟草吸烟与初级开角眼光障碍 (POAG) 之间没有显著的联系. 卫生促进工作仍然应该优先考虑戒烟,因为它对健康有严重的风险.
科学领域:
- 眼科医生 眼科 眼科
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 玻璃眼是全球不可逆转失明的主要原因.
- 主要开角玻璃眼 (POAG) 是最常见的玻璃眼形式.
- 之前关于烟草吸烟和POAG的研究已经产生了相互矛盾的结果.
研究的目的:
- 系统地审查和元分析烟草吸烟与初级开角玻璃眼 (POAG) 之间的关联.
- 为了澄清当前,过去和联合吸烟和POAG发展之间的关系.
主要方法:
- 在EMBASE,MEDLINE和Web of Science数据库中进行系统搜索,直到2025年4月.
- 包括观察性和随机对照性研究,并对成年人吸烟和POAG进行统计分析.
- 使用ROBINS-E工具进行偏差风险评估,使用RevMan软件进行元分析.
主要成果:
- 分析了26项涉及289930名参与者的研究,其中包括6454例POAG病例.
- 与从未吸烟者相比,当前吸烟者 (OR=1.00),过去吸烟者 (OR=0.92),或组合吸烟者 (OR=1.00) 和POAG之间没有发现统计学意义上的关联.
- 在观察性研究中发现了高异质性和偏差风险;在排除高风险研究后,研究结果保持一致.
结论:
- 目前的证据表明,烟草吸烟与原发性开角玻璃眼之间没有统计学意义上的关联.
- 尽管缺乏与POAG的直接联系,但烟草戒烟仍然对整体健康促进至关重要,因为它对全身和眼部健康产生了广泛的负面影响.
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