神经肌肉疾病中的REM相关阻塞性睡眠呼吸暂停:一项10年后期的队列研究
Merve Sinem Oguz1, Esen Kiyan2, Aylin Pihtili3
1Department of Pulmonary Diseases, İskenderun State Hospital, Hatay, Turkey.
Sleep & breathing = Schlaf & Atmung
|February 2, 2026
概括
阻塞性睡眠呼吸暂停 (OSA) 在神经肌肉疾病 (NMD) 中很常见,特别是在快速眼动 (REM) 睡眠期间. 与REM相关的OSA与早晨高头和肺功能下降相关,这表明它可能预测呼吸衰竭.
科学领域:
- 神经学 神经学
- 肺部病理学 肺部病理学
- 睡眠医学 睡眠医学
背景情况:
- 神经肌肉疾病 (NMDs) 与快速眼动 (REM) 睡眠期间阻塞性呼吸暂停/呼吸暂停增加有关.
- 在NMD中,与REM相关的阻塞性睡眠呼吸暂停 (OSA) 的特定患病率和临床相关性尚未明确.
研究的目的:
- 为了评估NMD患者的REM睡眠特征.
- 在这个人群中确定REM相关OSA的频率.
- 确定与REM相关的OSA相关的人口和临床因素.
主要方法:
- 从290名患有NMD的患者 (2015-2024) 获得的多睡眠图 (PSG) 数据的回顾性分析.
- 收集人口统计数据,早晨动脉血液气体和螺旋计.
- 根据REM和非REM (NREM) 睡眠期间的特定呼吸暂停-低呼吸指数 (AHI) 标准,定义了与REM相关的OSA.
主要成果:
- 在NMD队列中,OSA患病率很高 (87.6%).
- 雷姆睡眠的持续时间显著减少.
- 在充足REM睡眠的患者中,54.4%患有REM相关的OSA,这与女性性别,高血压和抑郁症有关.
- 与REM相关的OSA独立地与早晨头增大,强迫生命能力降低 (FVC) 和轻度OSA严重程度相关.
结论:
- 阻塞性睡眠呼吸暂停 (OSA),特别是REM相关的OSA,在患有神经肌肉疾病 (NMDs) 的患者中普遍存在,尽管REM睡眠减少.
- 患有REM相关的OSA的患者中,早晨高头和FVC下降更为频繁.
- 快速眼动睡眠模式可能成为NMD中慢性呼吸衰竭发展的预测因素.
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