胰腺切除术后代谢功能障碍相关的脂肪性肝病:一种被低估的代谢并发症,由独特的病理生理机制驱动
Andrea Tehuitzil-Cordero1, Eduardo Montalvo-Javé2,3, Misael Uribe2
1Traslational Research Unit, Medica Sur Clinic & Foundation, Puente de Piedra 150. Toriello Guerra Tlalpan. Z.C., Mexico City, 14050, Mexico.
Journal of gastrointestinal cancer
|February 2, 2026
概括
代谢功能障碍相关的脂肪性肝病 (MASLD) 是胰腺切除术 (PD) 后的一种严重并发症,影响8-37%的患者. 早期的酶疗法和特定的手术方法可以减轻其对癌症治疗的影响.
科学领域:
- 胃肠病学和肝病学
- 手术瘤学手术瘤学
- 代谢疾病 代谢疾病
背景情况:
- 胰腺二管切除术 (PD) 是对周和胰腺癌的关键手术.
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一种新出现的并发症,影响长期PD结果.
研究的目的:
- 审查发生率,病理生理学,临床影响和PD后新型MASLD的管理.
- 突出MASLD对胃肠道恶性瘤患者的影响.
主要方法:
- 临床和翻译研究的叙述性审查.
- 专注于肝硬化,代谢障碍,胰腺功能不充分以及PD后的化疗效应.
- 评估营养状况,肝脏发病率和瘤治疗的影响.
主要成果:
- 在PD的一年内,新发MASLD会影响8-37%的患者.
- 手术后的MASLD源于胰腺外分缺陷,吸收不良和失生症,导致肝脏脂毒性.
- 进展为脂肪肝炎或纤维化可以限制化疗耐受性;酶替代和特异性切除显示出希望.
结论:
- MASLD是PD的明显,显著的术后并发症,具有瘤学影响.
- 系统性肝脏监测和多学科护理对于PD后的胃肠癌患者至关重要.
相关概念视频
What is Metabolism?
131.8K
Overview
131.8K
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
199
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
199
Carbohydrate Metabolism
14.2K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
14.2K
Overview of Metabolism
38.2K
Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
38.2K
Regulation of Metabolism
11.6K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
11.6K
Metabolic Rate
1.2K
The human body is a powerhouse of energy, with every cell performing numerous functions that require energy. This energy production and consumption is measured by the metabolic rate, which quantifies the total heat generated by all the body's chemical reactions and mechanical work. This measurement helps to determine the rate of kilocalorie (kcal) consumption needed to fuel all ongoing activities.
The Basal Metabolic Rate (BMR) measures the energy expended at rest.
Several factors influence...
The Basal Metabolic Rate (BMR) measures the energy expended at rest.
Several factors influence...
1.2K


