子宫内膜微生物群-二甲基甘氨酸-Treg细胞轴影响子宫内膜受容性在重复的植入失败中
Fen-Ting Liu1,2,3,4, Ping Zhou1,2,3,4, Feng Deng1,2,3,4
1Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China.
Science China. Life sciences
|February 2, 2026
概括
复发性植入失败 (RIF) 与子宫内膜微生物群和代谢物的变化有关. 恢复二甲基甘氨酸 (DMG) 可能通过支持调节性T细胞来改善子宫内膜受体性和减少RIF.
科学领域:
- 生殖生物学 生殖生物学
- 微生物组研究的研究.
- 代谢学 代谢学 代谢学
背景情况:
- 复发性植入失败 (RIF) 是辅助生殖技术的一个重大挑战,其病因不明.
- 新出现的证据表明,生殖道微生物群不平衡与RIF之间存在联系.
- 了解子宫内膜微生物组的作用对于改善RIF治疗至关重要.
研究的目的:
- 调查RIF患者和对照组之间的子宫内膜微生物群和代谢物的差异.
- 探索子宫内膜微生物群改变对子宫内膜受体性的功能影响.
- 为了确定RIF的潜在治疗目标.
主要方法:
- 对子宫内膜微生物群 (EnM) 和子宫洗液微生物群 (UfM) 多样性的比较分析.
- 对子宫内膜组织的代谢分析.
- 微生物群和代谢物之间的相关性分析.
- 在老鼠模型中移植微生物群.
- 对子宫基因表达 (Hoxa-10,Lif) 和免疫细胞群 (Treg) 的评估.
主要成果:
- 在RIF和对照组之间,EnM和UfM的α和β多样性的显著差异.
- 在RIF患者中,子宫内膜代谢物的变化,包括二甲基甘氨酸 (DMG) 的降低.
- 特定微生物种类和代谢物之间的相关性.
- 在老鼠中,EnM移植降低了子宫受容性标记物 (Hoxa-10,Lif),植入点和Treg细胞.
- 移植也降低了DMG表达.
结论:
- 在RIF患者中,子宫内膜微生物群的变化与子宫内膜代谢物的变化有关.
- 这些变化可能导致调节性T细胞减少和子宫内膜受体受损,导致RIF.
- 补充DMG显示有潜力抵消微生物群诱导的子宫内膜接受力的损害.
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