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Updated: Feb 4, 2026

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增强仿真抗原受体T细胞功能的策略和机制
Shi Han1,2,3, Juan Yue1,2,3, Haiqiong Zheng1,2,3
1Bone Marrow Transplantation Center of The First Affiliated Hospital & Liangzhu Laboratory, Zhejiang University School of Medicine, Hangzhou, 310000, China.
Science China. Life sciences
|February 2, 2026
概括
审查了增强仿真抗原受体-T (CAR-T) 细胞治疗功能的策略. 优化CAR分子,基因编辑和组合疗法有望提高抗瘤疗效,减少癌症治疗中的复发.
科学领域:
- 免疫学和瘤学
- 细胞疗法细胞疗法
背景情况:
- 化学抗原受体-T (CAR-T) 细胞疗法显示出治疗恶性瘤的前景.
- 临床应用面临挑战,包括由于CAR-T细胞功能不足而导致的低响应率和瘤复发.
研究的目的:
- 系统地审查提高CAR-T细胞功能的策略.
- 确定改善CAR-T细胞疗效和克服临床局限性的方法.
主要方法:
- 审查CAR分子的结构修饰和基因编辑.
- 对制造过程优化的分析.
- 对增强CAR-T细胞对瘤免疫微环境的策略的评估.
- 评估与其他药物的联合疗法.
主要成果:
- 双目标CARs防止抗原逃逸,并增强CAR-T细胞的激活,增殖和抗瘤功效.
- 基因编辑改善了CAR-T细胞的持久性,增殖和抗瘤活性,减少了复发.
- 表观遗传调节和组合疗法为增强抗瘤效果和整体治疗疗效提供了新的方法.
结论:
- 目前的策略,如双目标CARs,基因编辑和表观遗传调节,显著提高CAR-T细胞的功能.
- 基因编辑精度,表观遗传可逆性和CAR结构优化的挑战需要进一步研究.
- 未来的研究应该专注于协同应用,以最大限度地发挥CAR-T细胞疗法的潜力,治疗更广泛的癌症.
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