通过基于AIEgen的共价有机框架克服化学阻力
An Song1,2, Qing Wang1, Bo-Yu Liu3
1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan 430079, China.
Nano letters
|February 2, 2026
概括
一种新型的共价有机框架 (COF) 纳米药物通过抑制癌症干和免疫抑制,有效地准耐化学性癌症. 这种突破性的纳米医学显示出治疗复发性瘤和改善患者治疗结果的巨大潜力.
科学领域:
- 生物医学工程 生物医学工程
- 材料科学 材料科学 材料科学
- 癌症研究 癌症研究
背景情况:
- 化学抵抗是癌症治疗中的一个重要障碍,导致治疗失败,瘤复发和死亡率增加.
- 迫切需要有效的策略来克服化学抵抗并提高患者的生存率.
研究的目的:
- 开发和评估一种新的共价有机框架 (COF) 纳米医学,3N-DPQ-COF,用于向和治疗耐化学性癌症.
- 研究3N-DPQ-COF克服化学抵抗的机制,包括其对癌症干细胞,瘤微环境 (TME) 和免疫激活的影响.
主要方法:
- 基于AIEgen的COF纳米药物的合成和表征,3N-DPQ-COF.
- 在化学耐药4T1和CT26癌症模型中对3N-DPQ-COF的体外和体内评估.
- 评估3N-DPQ-COF对癌症干细胞的影响,TME组成 (CD8+ T细胞,骨髓系衍生抑制细胞,红色素原始细胞) 和热诱导 (依赖GSDME).
主要成果:
- 3N-DPQ-COF在耐药瘤细胞中表现出高效的积累和抑制癌症干细胞,在4T1和CT26模型中表现优于多克索鲁比辛.
- 这种纳米药物促进了CD8+T细胞的透,减少了免疫抑制细胞,并诱导了GSDME依赖性热,有效地重塑了TME.
- 值得注意的是,3N-DPQ-COF抑制了化学抵抗性瘤的转移和复发,达到90%以上的瘤抑制率和超过80%的治愈率,而没有检查点阻塞.
结论:
- 以AIEgen为基础的COF纳米药物,以3N-DPQ-COF为例,为克服化学抵抗提供了一个有希望的策略.
- 通过3N-DPQ-COF同时调节瘤干,热和免疫激活,为癌症治疗提供了一种强有力的方法.
- 这项研究强调了先进纳米药物在解决瘤学的关键挑战,包括转移和复发方面的治疗潜力.
相关概念视频
01:29Covalent Bonds
162.3K
Overview
162.3K
01:08Covalent Bonds
11.0K
Overview
When two atoms share electrons to complete their valence shells, they create a covalent bond. An atom's electronegativity—the force with which shared electrons are pulled towards an atom—determines how the electrons are shared. Molecules formed with covalent bonds can be either polar or nonpolar. Atoms with similar electronegativities form nonpolar covalent bonds; the electrons are shared equally. Atoms with different electronegativities share electrons unequally,...
When two atoms share electrons to complete their valence shells, they create a covalent bond. An atom's electronegativity—the force with which shared electrons are pulled towards an atom—determines how the electrons are shared. Molecules formed with covalent bonds can be either polar or nonpolar. Atoms with similar electronegativities form nonpolar covalent bonds; the electrons are shared equally. Atoms with different electronegativities share electrons unequally,...
11.0K
02:18Network Covalent Solids
16.2K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.2K
02:04Covalently Linked Protein Regulators
9.6K
Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
These groups modify specific amino acids in a protein....
9.6K
02:04Covalently Linked Protein Regulators
2.0K
2.0K
02:46Covalent Bonding and Lewis Structures
61.3K
Compared to ionic bonds, which results from the transfer of electrons between metallic and nonmetallic atoms, covalent bonds result from the mutual attraction of atoms for a “shared” pair of electrons.
61.3K