脂肪酸衍生型的肌体血管分量注射用于辐射诱导的膀纤维化:首次在人身上进行试点研究
Roger Klein1, Nerone Douglas2, Asim Ejaz2,3
1Department of Urology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, United States.
Stem cells translational medicine
|February 2, 2026
概括
这项试点研究表明,在膀中注射流体血管分细胞是安全的,并且可用于治疗辐射诱导的膀纤维化. 需要进一步的研究来确定这种细胞治疗的最佳剂量和患者选择.
科学领域:
- 再生医学是一种再生医学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 细胞疗法细胞疗法
背景情况:
- 盆腔放射治疗可能会导致膀功能障碍,包括降低服从性和detrusor过度活跃.
- 介质干细胞产品在动物模型中显示有望减少辐射诱导的炎症和纤维化.
- 脂质衍生体血管分离 (SVF) 是一种含有各种细胞类型的细胞产物,具有潜在的治疗性质.
研究的目的:
- 评估内脂肪衍生的肌体血管分量注射用于治疗膀纤维化的安全性和可行性.
- 评估这种细胞治疗在改善尿路症状和尿道流量参数方面的疗效.
- 建立未来临床试验的基础,用于治疗辐射引起的膀并发症的细胞疗法.
主要方法:
- 这是一项首次在人身上进行的试点研究,该研究涉及一名82岁的男性患者,他曾经接受过前列腺癌支臂治疗.
- 在局部麻醉下采集皮下脂肪组织,并使用SVF-2装置处理以分离流体血管分量 (SVF).
- 该SVF细胞产品通过静脉内注射到膀壁,使用柔性囊镜进行了注射.
- 患者的安全性和结果被监测了16个月,使用囊镜,膀活检,MRI和泌尿动力学.
主要成果:
- 这项手术是安全的,可行的,没有术后并发症.
- 患者经历了自我限制的手术后症状 (失尿症,出血症,伤).
- 尿症状和尿流参数在6个月内保持稳定,在15个月后略有进展.
- 重复的囊镜和活检显示疾病稳定,没有二次恶性瘤问题.
- 12个月的MRI和15个月的泌尿动力学没有显示出与基线相比的显著变化.
结论:
- 内脂肪衍生的SVF注射是一种安全和可行的方法,用于治疗放射治疗后的膀纤维化.
- 这项试点研究为设计未来临床试验提供了关键数据.
- 进一步的研究是有必要的,以优化剂量,患者选择,和治疗方案细胞疗法在辐射诱导的膀损伤.
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