益生菌效应分子的功能多样性:了解它们在改善肠道健康方面的作用
Xiaoyue Bai1, Yizhi Jing2, Ming Zhang3
11College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China;
Annual review of food science and technology
|February 2, 2026
概括
益生菌使用效应分子 (PEM) 与宿主相互作用,影响肠道健康和免疫力. 了解PEM是开发向益生菌疗法和功能性食品的关键.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 益生菌通过分泌或与表面相关的生物活性化合物,称为益生菌效应分子 (PEMs) 来调节宿主健康.
- PEM包括各种分子,如外聚糖,蛋白质,,囊泡和代谢物,调解关键的宿主微生物相互作用.
研究的目的:
- 审查各种类型的PEM及其在宿主微生物交叉交流中的作用机制.
- 突出PEM识别和应用中的挑战.
- 探索利用PEM在治疗和营养环境中的新兴策略.
主要方法:
- 文献综述和关于益生菌效应分子的当前研究的综合.
- 对PEM产生和宿主受体相互作用 (例如TLRs,GPCRs,AhRs) 的分子机制的分析.
- 讨论先进的技术,包括比较基因组学和合成生物学.
主要成果:
- 孕产妇增强上皮屏障,调节肠道微生物群的组成,调节免疫反应.
- PEM活性是菌株特异性的,受到环境因素的影响,需要了解受体相互作用的有效性.
- 在高通量PEM识别,现场验证和剂量确定方面仍然存在重大挑战.
结论:
- 对PEM多样性和功能的全面理解对于推动益生菌研究至关重要.
- 新兴技术为释放PEM的治疗潜力提供了有希望的途径.
- 针对性益生菌疗法和创新的功能性食品可以基于对PEM的机械洞察力来设计.
相关概念视频
Physiology of Enteric Nervous System and Gut Health
981
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
981
Role of Vitamins in Maintaining Bone Health
5.5K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.5K
Molecules and Compounds
68.7K
Atoms and Molecules
68.7K
Cell Adhesion Molecules - Types and Functions
9.3K
Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily involved...
CAM Families
The Integrin family of proteins is primarily involved...
9.3K
Diversity of Archaea I
639
Archaea, a domain of single-celled microorganisms, are classified into five major phyla based on genetic and biochemical characteristics: Euryarchaeota, Crenarchaeota, Thaumarchaeota, Korarchaeota, and Nanoarchaeota. Among these, the phylum Euryarchaeota is notable for its remarkable diversity in morphology, metabolism, and ecological adaptations.Morphological and Metabolic DiversityMembers of Euryarchaeota exhibit a variety of cellular shapes, including rods and cocci. Their metabolic pathways...
639
Cell Diversity
5.1K
The concept of a cell started with microscopic observations of dead cork tissue by Robert Hooke in 1665. Hooke coined the term "cell" based on the resemblance of the small subdivisions in the cork to the rooms that monks inhabited, called cells. About ten years later, Antonie van Leeuwenhoek became the first person to observe the living and moving cells under a microscope. In the century that followed, the theory that cells represented the basic unit of life developed.
Multicellular...
Multicellular...
5.1K


