细针吸收活检T细胞非霍奇金淋巴瘤的诊断:形态特征,辅助检测和诊断陷
Acta cytologica
|February 2, 2026
概括
精细针吸收活检 (FNAB) 有助于诊断T细胞和NK细胞淋巴瘤,为T-LBL和ALCL等一些亚型提供最终诊断. 然而,其他淋巴瘤可能需要组织学来准确分类.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 细胞病理学 细胞病理学
背景情况:
- T细胞和NK细胞淋巴瘤是具有不同表现的侵袭性淋巴状瘤.
- 准确的分类对于患者管理至关重要,并依赖于综合诊断方法.
研究的目的:
- 审查各种T细胞淋巴瘤的细胞学特征和辅助测试资料.
- 强调使用细针吸收活检 (FNAB) 的实用诊断算法.
- 突出细胞病理学在根据世卫组织指导方针对这些淋巴瘤进行分类方面的作用和局限性.
主要方法:
- 对T-淋巴细胞淋巴瘤 (T-LBL),全身性大细胞淋巴瘤 (ALCL),与乳房植入物相关的ALCL (BIA-ALCL),结节T毛囊辅助细胞淋巴瘤 (nTFHL-AI),肝性T细胞淋巴瘤 (HSTL) 和外围T细胞淋巴瘤 (PTCL-NOS) 的细胞学特征的综述.
- 免疫细胞化学,流细胞计 (包括TRBC1) 和分子克隆性测试的整合.
- 强调诊断算法,陷和特定情况下组织学的必要性.
主要成果:
- FNAB可以为T-LBL,全身ALCL和BIA-ALCL输出提供明确或近乎明确的诊断.
- 对于nTFHL-AI和PTCL-NOS等实体,FNAB主要引起怀疑并指导组织活检.
- 细胞形态重叠可能会限制FNAB在没有辅助测试的情况下进行完全分类的能力.
结论:
- 配合适当的辅助技术,FNAB对于诊断和亚型T细胞淋巴瘤非常有价值.
- 了解细胞病理学的极限对于最佳的患者管理和报告至关重要.
- 细胞学,免疫类型和分子研究的整合符合世卫组织的分类系统.
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