挖掘FAERS数据库揭示了在瘤实践中使用120毫克德诺苏马布的新安全信号
Shaohuan Lu1, Dongxiao Wang2, Caiming Xiong3
1Department of Pharmacy, The First People's Hospital of Yulin, Yulin, Guangxi, China.
PloS one
|February 2, 2026
概括
这项研究确定了120毫克德诺苏马布的294个不良药物事件信号,包括骨缩和死亡. 临床医生应监测已知和新出现的毒性,以确保患者的安全.
科学领域:
- 药物监督 药物监督 药物监督
- 药品安全 药品安全
- 在瘤学瘤学.
背景情况:
- 德诺苏马布是一种用于瘤学的单克隆抗体.
- 现实世界的数据对于理解药物安全性概况至关重要.
- 药物不良事件 (ADEs) 需要持续监测.
研究的目的:
- 在现实环境中检测和量化与120毫克德诺苏马布相关的不良药物事件 (ADE) 信号.
- 识别既有和新出现的安全问题.
- 为增强患者安全协议提供数据.
主要方法:
- 使用了美国食品和药物管理局不良事件报告系统 (FAERS) 数据库.
- 分析了10963份120毫克德诺苏马布的报告.
- 使用报告几率比率 (ROR) 和贝叶斯信任传播神经网络 (BCPNN) 的不成比例分析.
主要成果:
- 在27个系统器官类 (SOC) 中识别了294个积极的不成比例信号.
- 最常见的不良事件包括骨 (28.11%),死亡 (7.32%) 和低血症 (7.29%).
- 最强烈的信号是骨巨细胞瘤和大骨;确定了32个未列出的事件.
结论:
- 临床医生必须对已知的毒性和32个新出现的安全信号保持警.
- 确保患者安全需要对已确定的和新的ADEs进行监测.
- 这些发现支持120毫克denosumab的患者的积极安全管理.
相关概念视频
Survey Safety
396
Surveying near highways, rough terrain, or power lines involves significant risks. Working along highways is particularly dangerous and requires the use of warning signs and flagmen. It is safest to avoid working directly on roads and use offsets whenever possible. When highway work is unavoidable, it must follow all safety guidelines. Surveyors should wear bright clothing, such as orange reflective vests, to ensure visibility to motorists, coworkers, and hunters. In construction zones, wearing...
396
Household Wiring And Electrical Safety
1.7K
Companies that supply power to most modern households use three conductors, typically called a three-wire line. While one is neutral, the other two are both at 120 V but with opposite polarity, giving a voltage of 240 V between them. With a three-wire line, high-power appliances that require 240 V, such as electric stoves and clothes dryers, are linked between the two hot lines. 120 V appliances can be connected between the neutral and either of the hot lines. The neutral side, which is always...
1.7K
Characteristics of Practical Op Amps
864
A difference amplifier, a crucial component in numerous electronic devices, ideally amplifies only the difference-mode signal, which is the difference between two input signals. However, in practical circuits, the output voltage depends on both the differential gain and the common-mode gain.
The ratio of differential gain to the common-mode gain is defined as the common-mode rejection ratio (CMRR). This ratio quantifies the ability of operational amplifiers (op-amps) to reject common-mode...
The ratio of differential gain to the common-mode gain is defined as the common-mode rejection ratio (CMRR). This ratio quantifies the ability of operational amplifiers (op-amps) to reject common-mode...
864
Theoretical Foundations of Nursing Practice
17.4K
Theories play an essential role in organizing patient care. Theories refer to a proposed or followed belief, policy, or procedure that is the basis for action. Nursing theories are knowledge-based concepts that guide nurses' actions, influence nursing education and practice, and allow nurses to care for their patients.
Theories provide a perspective to assess patients' conditions and organize data and methods. They also assist in analyzing and interpreting information. They represent a...
Theories provide a perspective to assess patients' conditions and organize data and methods. They also assist in analyzing and interpreting information. They represent a...
17.4K
Equivalent Circuits for Practical Transformers
1.4K
The practical equivalent circuits of single-phase two-winding transformers exhibit significant deviations from their idealized versions due to the inherent properties of winding resistance and finite core permeability. These properties result in real and reactive power losses, affecting the transformer's performance. Understanding these deviations is crucial for designing more efficient transformers.
In a practical transformer, each winding exhibits resistance and leakage reactance. The...
In a practical transformer, each winding exhibits resistance and leakage reactance. The...
1.4K
Endocrine Signaling
68.1K
Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
68.1K


