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Updated: Feb 4, 2026

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通过向BRD4的小分子ZL058080进行机械洞察和体内HIV抑制

Naveen Kumar1, Zonghui Ma2, Fuquan Long1,3

  • 1Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, United States of America.

PLoS pathogens
|February 2, 2026
PubMed
概括

一种新型药物ZL0580选择性地向BRD4以抑制HIV转录. 在小鼠中,ZL0580降低了病毒载量和延迟了反弹,显示了治愈艾滋病毒的潜力.

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