优化宫癌查根据年龄在人乳头瘤病毒疫苗接种:健康和资源的影响
Kine Pedersen1, Jacopo Di Silvestre1, Stephen Sy2
1University of Oslo, Department of Health Management and Health Economics, Oslo, Norway (K.P., J.Di S.).
Annals of internal medicine
|February 2, 2026
概括
人类乳头瘤病毒 (HPV) 广泛疫苗接种需要调整宫癌 (CC) 查. 对接种疫苗的人来说,较少频繁的查是具有成本效益的,根据接种疫苗的年龄量身定制的策略.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 卫生经济学 卫生经济学
背景情况:
- 广泛的人类乳头瘤病毒 (HPV) 疫苗接种显著影响子宫癌 (CC) 风险.
- 这就需要调整当前的CC查计划,以考虑疫苗接种情况.
研究的目的:
- 评估基于HPV疫苗接种年龄的修改CC查策略的成本效益和危害益处权衡.
- 为疫苗接种群体确定最佳查间隔和频率.
主要方法:
- 一个基于个人的数学建模研究,使用挪威公布的数据.
- 模拟的假设队列在不同年龄段 (12-30岁) 用双价或非价HPV疫苗接种疫苗.
- 评估终身查策略的开始年龄,间隔和测试数量各不相同,使用每QALY55,000美元的成本效益值.
主要成果:
- 对于在24岁之前接种疫苗的妇女来说,更少频繁的查 (每15-25年一次) 是首选的,只需要2-3次终身查.
- 减少查频率的偏好在不同的疫苗接种年龄和疫苗类型中保持,即使不完全遵守.
- 查策略因疫苗接种时的年龄和疫苗类型而异.
结论:
- 优化的宫癌查计划应包括30岁之前接种HPV疫苗的个体的少频查.
- 查策略可以根据HPV疫苗接种年龄和接种的特定疫苗进行个性化.
- 这些调整确保了成本效益,并平衡了利益与潜在的危害.
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