高压氧改善了老鼠的药物诱导的联合高尿血病模型,通过重塑肠道微生物群和调节宿主新陈代谢
Ya Li1, Xinxin Li1, Huaxian Li2
1Department of Aerospace Hygiene, School of Aerospace Medicine, Fourth Military Medical University, Xi'an, China.
Biochemical and biophysical research communications
|February 2, 2026
概括
高压氧疗法 (HBO) 通过改善肠道微生物群和宿主新陈代谢,有效地治疗大鼠药物诱导的高尿血 (HUA). 这种非药理学方法为HUA提供了新的治疗点.
科学领域:
- 生物医学科学 生物医学科学
- 代谢学 代谢学 代谢学
- 微生物组研究 微生物组研究
背景情况:
- 尿酸过高 (Hyperuricemia,简称HUA) 是一种以尿酸水平升高为特征的疾病.
- 药物诱导的HUA模型对于研究治疗干预至关重要.
- 了解HUA的潜在机制对于开发有效的治疗方法至关重要.
研究的目的:
- 调查高压氧 (HBO) 对药物诱导的高尿血 (HUA) 的小鼠模型的改善作用.
- 阐明HUA中HBO治疗的潜在机制,重点关注肠道微生物群和宿主代谢.
主要方法:
- 使用酵母,氧酸和低素建立了HUA的老鼠模型.
- 在建模过程中进行了HBO治疗.
- 测量了血清尿酸 (UA),肌素 (Cr) 和血尿素 (BUN) 的水平.
- 进行了HE染色,以对小肠和脏组织进行基因病理学评估.
- 进行了血清非向代谢和16S rRNA基因测序,用于肠道微生物群分析.
主要成果:
- 在HUA大鼠中,HBO治疗显著降低了血清UA,Cr和BUN水平.
- 在小肠和脏组织中,HBO疗法减轻了他的病理损伤.
- HBO疗法调节了肠道微生物群结构,减少了潜在的致病细菌.
- HBO治疗降低了Bacteroides和Alistipes的相对丰度,减少了内源性UA的产生.
- 血清代谢学表明,HBO治疗改善了HUA大鼠的差异代谢物,特别是谷氨和d-谷氨胺/d-谷氨酸代谢途径.
- HBO治疗调节了纯氨酸和氨基酸代谢,促进了与UA分泌相关的代谢产物.
结论:
- 高压氧气疗法对大鼠药物诱导的高尿素血症产生了显著的治疗效果.
- 通过重塑肠道菌群和调节宿主代谢途径,HBO疗法可以改善HUA.
- 这项研究提供了HBO作为HUA潜在的非药物治疗方法的实验证据,并确定了潜在的治疗点.
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