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perfluorohexyloctane 在人类肝细胞中的代谢作用和生物转化

Andi Alijagic¹, Jade Chaker², João Marcos G Barbosa²

¹Man-Technology-Environment (MTM) Research Centre, School of Science and Technology, Örebro University, SE-701 82 Örebro, Sweden; Inflammatory Response and Infection Susceptibility Centre (iRiSC), Örebro University, Örebro SE-701 82, Sweden; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, SE-701 82 Örebro, Sweden.

Environment international

|February 2, 2026

概括

perfluorohexyloctane (F6H8),用于干眼,导致肝细胞显著的代谢变化. 这种半化基可能不是惰性的,并且由于潜在的毒性,需要进一步评估安全性.

科学领域:

肝病学肝病学是一种肝病学.
毒理学毒理学毒理学
代谢学代谢学代谢学

背景情况:

perfluorohexyloctane (F6H8) 是一种半化基,用于治疗干眼病的眼科治疗.
人们对其系统积累和长期毒性存在担忧,因为其结构与持久性per-和多醇基物质 (PFAS) 结构相似.

研究的目的:

为了研究F6H8暴露对肝脏的潜在影响.
为了检查F6H8在人类HepaRG肝细胞中的代谢影响,通过模拟短期和长期暴露场景的度范围.

主要方法:

人类HepaRG肝细胞在广泛的度范围内暴露于F6H8.
在细胞内和细胞外样本上使用超高性能液体染色学-四极飞行时间质谱法 (UHPLC-QTOFMS) 进行了组合的向和非向代谢分析.

主要成果:

F6H8诱导了依赖度的代谢变化,许多人表现出非单调的反应.
低度的F6H8影响了氨基酸,脂肪酸和脂质代谢;高度破坏了中央碳代谢.
检测到一种生物转化产物,即 perfluorohexyloctanoic acid,这表明代谢持久性和明显的生物活性.

结论:

F6H8在肝细胞中引起广泛的代谢重编程,并且可能不是代谢惰性的.
这些发现强调了对F6H8和相关的半基进行全面的长期安全评估的必要性,考虑到它们的临床用途和结构类似于持久化物.

关键词:

这就是HepaRGG.利皮多米克 (Lipidomics) 是一种消化剂.肝脏新陈代谢肝脏的新陈代谢代谢学代谢学代谢学在PFAS中,我们可以使用PFAS.perfluorohexyloctane 是一种含有多的化合物.

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