热力学不确定性关系限制了通过细胞信号系统传输信息
Shreyansh Verma1, Vishva Saravanan R2, Bhaswar Ghosh3
1International Institute of Information Technology Hyderabad, Gachibowli, Hyderabad, Telangana, 500032, INDIA.
Physical biology
|February 2, 2026
概括
生物系统需要能量,因为产生. 热力学不确定性关系 (TUR) 限制了波动,提高了在压力下酵母信号通路中细胞信息传输的准确性.
科学领域:
- 生物物理学的生物物理.
- 细胞生物学 细胞生物学
- 系统生物学 系统生物学
背景情况:
- 生物系统的运行处于不平衡状态,需要持续的能量供应来产生不平衡的.
- 热力学不确定性关系 (TUR) 定义了相对于生产率的当前波动的下限.
- 生物系统的波动会影响信号噪声比,限制信息传输的准确性.
研究的目的:
- 调查TUR对蜂信号系统信息传输能力的影响.
- 分析转录因子 (TF) 动态和随机性在细胞信息处理中的作用.
- 阐明热力学波动和的产生如何影响在压力条件下的细胞信号.
主要方法:
- 结合数学建模和机器学习方法应用于酵母的实验数据.
- 在细胞信号通路内分析转录因子扩散和激活动态.
- 基于 TUR 的理论建模,以了解信息传输上的热力学约束.
主要成果:
- TFs向核的激活和偏向扩散会产生的产生.
- 这个过程放大了TF电流,减少了波动,提高了信息传输的准确性.
- 观察到遵守TUR边界,证明它们在细胞信息处理中的作用.
结论:
- 图尔在优化蜂信号传输中的信息传输准确度方面发挥着至关重要的作用.
- 的产生和热力学波动是细胞信息处理的关键机制.
- 该研究提供了TF的工作原理及其在压力下监管的见解.
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