降低血小板聚合,尽管增加可溶性P-选择素在怀孕期间的妇女和没有异合体因子V莱登突变V莱登突变
Margunn Bye Tøsdal1,2, Turid Helen Felli Lunde3,4, Tor Hervig2
1Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway.
Thrombosis and haemostasis
|February 2, 2026
概括
怀孕增加了静脉血栓栓塞 (VTE) 的风险. 这项研究发现,虽然血小板激活标志物在怀孕期间上升,但血小板聚合量下降,在患有V因子莱登突变 (FVL) 的女性中没有发现差异.
科学领域:
- 血液学 血液学 血液学
- 产科 产科 产科 产科 产科
- 血栓形成研究研究
背景情况:
- 怀孕和产后期间与静脉血栓栓塞 (VTE) 风险增加有关.
- 异卵性因子V莱登突变 (FVL) 与怀孕的白人女性中40%的VTE有关.
- 血生成,由血放大,在FVL个体和孕妇中增加,导致VTE,但FVL孕妇的血小板激活机制尚不清楚.
研究的目的:
- 在整个怀孕和产后期间跟踪血小板激活标志物血溶性P-选择素 (sP-选择素),全血小板聚合和血小板结晶学 (TEG) 参数.
- 为了确定异构性FVL在怀孕和产后期间是否影响这些参数.
主要方法:
- 招募了22名患有异合体FVL的孕妇和22名没有.
- 在怀孕期间和之后的多个时间点收集血液样本.
- 使用sP-选择素评估血小板激活和聚合,多电极聚合计 (MEA) 使用ADP,酸和TRAP-6激动剂,以及TEG.
主要成果:
- 怀孕期间sP-选择素水平显著增加 (P < 0.005).
- 血小板聚合在怀孕期间所有激动剂的反应下降.
- 在整个怀孕期间,TEG最大幅度 (MA) 增加.
- 在患有异性FVL和没有异性FVL的女性之间,没有观察到sP-选择素,血小板聚合或TEG参数的显著差异.
结论:
- 怀孕晚期的特点是血小板聚合减少和sP-选择蛋白增加,无论异性FVL状态如何.
- 异性FVL似乎不会在怀孕期间显著改变血小板功能.
- 在怀孕期间观察到的血小板聚合的减少需要进一步调查.
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