药物交付科学:它对下一代药物日益重要
Marianne Ashford1, Annette Bak2
1Advanced Drug Delivery, Pharmaceutical Sciences, R & D, AstraZeneca, Macclesfield, UK.
概括
药物输送创新对于新的治疗方式至关重要,如抗体药物合物和mRNA疗法. 早期将药物交付科学融入药物发现中,提高了药物的有效性和以患者为中心的配方.
科学领域:
- 制药科学 制药科学
- 药物运输 药物运输 药物运输
- 生物技术是生物技术.
背景情况:
- 制药行业正在扩大超越小分子的范围,以不同的治疗方式.
- 向药物合物 (例如抗体药物合物,寡核酸药物合物) 提供更好的疗效和减少副作用.
研究的目的:
- 审查药物模式类别及其特定的输送挑战.
- 总结当前的药物输送解决方案和新疗法趋势.
- 强调药物输送是早期药物发现的关键参数.
主要方法:
- 药物模式和输送策略的前景审查.
- 对配方和交付技术当前趋势的分析.
- 关于将药物交付科学纳入药物开发的讨论.
主要成果:
- 不同的方法 (生物制剂,核酸,合物) 需要量身定制的输送系统.
- 关键的输送解决方案包括无形固体分散,长效注射剂,高度生物制剂和mRNA的脂质纳米粒子.
- 针对性治疗对于改善治疗指数和降低剂量至关重要.
结论:
- 药物输送必须是设计的核心参数,而不是事后的想法,对于新的模式.
- 早期的合作和先进的 in vitro/in silico 工具对于翻译成功至关重要.
- 药物交付科学对于实现下一代药物和改善患者治疗结果至关重要.
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