设计,优化和表征一个热响应的水凝作为下注射剂,用于内镜切除
Tom L'Houtellier1, Mathieu Madau2, Edouard Roussel3
1CHU Rouen, Department of Pharmacy, F-76000 Rouen, France.
International journal of pharmaceutics
|February 2, 2026
概括
一种新的Poloxamer 407 (P407) 水凝为内镜手术提供了持续的下膜提升. 与盐水相比,这种热敏剂在内镜粘膜切除 (EMR) 和内镜亚粘膜解剖 (ESD) 期间提供更持久的缓冲.
科学领域:
- 生物材料科学 生物材料科学
- 胃肠病学 胃肠病学
- 内視鏡外科手術 內視鏡外科手術
背景情况:
- 粘膜下注是内镜粘膜切除 (EMR) 和内镜粘膜下剖析 (ESD) 的关键.
- 像普通盐水这样的当前溶液由于快速扩散,只能提供暂时的粘膜升高.
- 需要改进的提升剂,提供持续的粘膜下支.
研究的目的:
- 开发和表征一个热敏的poloxamer 407 (P407) 水凝,用于增强的下提升.
- 评估P407水凝用于内镜应用的物理化学,学和功能性质.
主要方法:
- 使用P407水凝实验设计方法进行配方优化.
- 凝性质的表征,质,度和pH值.
- 猪胃肠组织的体外降解研究和体外试验.
主要成果:
- 优化的20%P407配方在体温附近表现出理想的凝和稳定的类风学特性.
- 在ex vivo模型中,水凝证明了持续的粘膜提升,表现优于正常盐水.
- 无菌过和针穿透对水凝的特性影响最小.
结论:
- 热敏水凝P407显示出用于下注射的有希望的物理化学和功能特性.
- 它有可能在EMR和ESD程序中充当先进的提升剂.
- 建议进行进一步的体内评估,以确认安全性和临床疗效.
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