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相关概念视频

What is Gene Expression?01:42

What is Gene Expression?

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Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
196.7K
What is Gene Expression?01:36

What is Gene Expression?

11.4K
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
11.4K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

16.5K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.5K
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

24.8K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
24.8K
mRNA Stability and Gene Expression02:51

mRNA Stability and Gene Expression

6.7K
The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
6.7K
Fruit Development, Structure, and Function01:58

Fruit Development, Structure, and Function

25.2K
Fruits form from a mature flower ovary. As seeds develop from the ovules contained within, the ovary wall undergoes a series of complex changes to form fruit. In some fruits, such as soybeans, the ovary wall dries; in other fruits, such as grapes, it remains fleshy. In some cases, organs other than the ovary contribute to fruit formation; such fruits are called accessory fruits.
25.2K

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相关实验视频

Updated: Feb 4, 2026

Using an Automated Cell Counter to Simplify Gene Expression Studies: siRNA Knockdown of IL-4 Dependent Gene Expression in Namalwa Cells
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Using an Automated Cell Counter to Simplify Gene Expression Studies: siRNA Knockdown of IL-4 Dependent Gene Expression in Namalwa Cells

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发展中的神经元结构的基因表达图谱.

Leonardo Tadini1, Lilia Younsi2, Isabel Holguera1

  • 1Université Paris Cité, CNRS, Institut Jacques Monod, F-75013 Paris, France.

Developmental biology
|February 2, 2026
PubMed
概括

研究人员使用Novosparc算法创建了Drosophila光叶的3D基因表达图谱. 这个工具可以绘制细胞类型和基因模式的地图,帮助研究大脑发育和电路形成.

关键词:
德洛索菲拉 (Drosophila) 的视觉叶部分.诺沃斯帕克是一个新星.发育中的神经系统.神经发育的3D图书馆一个单细胞mRNA测序.空间转录学 空间转录学

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Determining the Role of Maternally-Expressed Genes in Early Development with Maternal Crispants
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In ovo Electroporation in Chick Midbrain for Studying Gene Function in Dopaminergic Neuron Development
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相关实验视频

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Using an Automated Cell Counter to Simplify Gene Expression Studies: siRNA Knockdown of IL-4 Dependent Gene Expression in Namalwa Cells

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Determining the Role of Maternally-Expressed Genes in Early Development with Maternal Crispants
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科学领域:

  • 神经科学是一个神经科学.
  • 发展生物学 发展生物学
  • 计算生物学 计算生物学

背景情况:

  • 大脑有数十亿个来自不同来源的神经元,需要精确的空间组织来整合电路.
  • 现有的单细胞mRNA测序图谱缺乏必要的空间信息,以了解大脑结构.
  • 空间转录学对于绘制神经元组织和发育过程至关重要.

研究的目的:

  • 重建基因表达和细胞类型在发育中的多索菲拉视叶的空间分布.
  • 开发一个用于可视化基因表达模式和识别空间模式转录因子的3D地图.
  • 为了解不同的神经元系如何融入功能性大脑电路提供一种工具.

主要方法:

  • 利用基因表达绘图算法Novosparc来分析空间转录基因数据.
  • 生成了Drosophila视的全面的三维 (3D) 地图集.
  • 确定了空间模式的转录因子,在地图中定义了特定的神经元类型.

主要成果:

  • 成功创建了Drosophila视的3D图谱,详细介绍了基因表达和细胞定位 (https://larva3dnovosparc.ijm.fr).
  • 确定了具有空间表达模式的关键转录因子,这些模式定义了不同的神经元类型.
  • 突出了Novosparc算法的局限性和潜在的改进,用于空间转录组分析.

结论:

  • 3D Drosophila 光叶图谱是研究大脑发育中的基因表达模式的宝贵资源.
  • 这项工作展示了空间转录学和算法方法用于绘制复杂大脑结构的潜力.
  • 这项研究为生成更复杂结构的3D大脑地图铺平了道路,推进了我们对神经电路形成的理解.