异素通过调节MAPK/NF-κB信号通路和调节肠道微生物群的结构来缓解骨关节炎
Aoyu Zhang1, Shuying Li2, Jie Qiao2
1College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Huangjiahu West Road 16, Wuhan 430065, PR China; Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, Hubei 430061, China; Hubei Shizhen Laboratory, Huayuanshan Road 4, Wuhan 430061, PR China.
Journal of ethnopharmacology
|February 2, 2026
概括
异素 (ISO) 通过调节肠道微生物群和抑制MAPK/NF-κB通路,有效治疗关节炎. 这种天然化合物可以减少炎症并改善骨健康,而不会引起肝脏或脏的毒性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 微生物学 微生物学
- 整形外科 整形外科 整形外科
背景情况:
- Psoralea corylifolia L. 在治疗关节疼痛的传统医学中有着悠久的历史.
- 来自Psoralea corylifolia L.的异索索拉 (ISO) 在治疗骨关节炎 (OA) 中表现有前途.
- OA涉及到局部关节问题和系统因素,包括肠道微生物群.
研究的目的:
- 在DMM诱导的骨关节炎模型中研究异沙 (ISO) 的治疗机制.
- 探索ISO对肠道微生物群,代谢物和炎症途径的影响.
主要方法:
- 网络药理学预测了ISO目标.
- 在体内研究评估治疗效果和安全性.
- 16S rDNA测序和代谢学分析了肠道微生物群和SCFA.
- 便微生物群移植 (FMT) 验证了肠道微生物群的作用.
主要成果:
- 国际标准组织证明了针对OA的多目标作用,降低了MAPK/NF-κB通路的调节.
- 在DMM小鼠中,ISO减弱了骨异常和关节退化.
- 根据ISO调节的肠道微生物群组成和SCFA水平,FMT证实了它的重要性.
- 没有观察到显著的肝脏毒性.
结论:
- 异素通过调节肠道微生物群和SCFA来缓解骨关节炎.
- ISO抑制MAPK/NF-κB通路,减少炎症和改善骨异常.
- ISO的治疗效果部分由肠道微生物群介导,没有观察到肝毒性.
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