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在HFD/STZ诱导的小鼠中,Agaricus bisporus多糖的抗糖尿病作用

Ziyang Wang¹, Qinqin Ouyang¹, Haiying Guo¹

¹Department of Nutrition and Health, Key Laboratory of Functional Dairy, China Agricultural University, Beijing, 100083, China.

International journal of biological macromolecules

|February 2, 2026

概括

阿加里克斯双多糖 (ABP) 显示出强大的抗糖尿病潜力,显著改善了2型糖尿病小鼠的症状. ABP有效地控制了血糖和胰岛素敏感性,为糖尿病提供了有前途的自然治疗方法.

科学领域:

生物化学生物化学
药理学药理学是一个学科.
营养科学营养科学

背景情况:

菌多糖因其潜在的治疗性质而闻名,包括抗糖尿病作用.
可食用真菌是生物活性化合物的丰富来源,具有潜在的健康益处.

研究的目的:

为了评估五种可食用的真菌多糖的抗糖尿病功效:Agaricus bisporus (ABP),Pleurotus eryngii (PEP),Boletus spp. (BP),Lentinus edodes (LEP) 和Pleurotus ostreatus (POP). 这两种类型的鱼类的种类是:
在小鼠模型中确定对2型糖尿病 (T2DM) 有最显著影响的多糖.

主要方法:

将五种真菌多糖给2型糖尿病小鼠.
评估生理学参数,包括体重,高食症,多食症,禁食葡萄糖,耐葡萄糖和胰岛素敏感性.
胰腺小岛,肝硬化和炎症的组织学检查.
分析胰岛素信号传递 (IRS1/PI3K/Akt) 和能量感应 (AMPK) 途径.
肝脏代谢学以确定代谢变化.

主要成果:

所有测试的多糖都显示出抗糖尿病作用,ABP显示出最显著的改善.
ABP显著改善了体重,减少了过度饮食,降低了禁食血糖,提高了葡萄糖耐受性和胰岛素敏感性.
组织学分析显示,ABP保留了胰腺小岛结构,并减少了肝硬化和炎症.
机理学研究表明,ABP激活了关键的代谢途径,包括胰岛素信号传递 (IRS1/PI3K/Akt) 和AMPK.
肝脏代谢学证实ABP有效地逆转了与糖尿病相关的代谢障碍.

结论:

与其他四种评估的真菌多糖相比,Agaricus bisporus多糖 (ABP) 显示出更高的抗糖尿病活性.
作为一种天然衍生治疗剂,ABP在治疗2型糖尿病方面具有显著的潜力.
对ABP的进一步研究可能会导致糖尿病治疗的新,自然干预措施.

关键词:

这是一种Agaricus bisporus多糖化合物.糖尿病糖尿病糖尿病菌的多糖类是真菌的多糖类.胰岛素的信号传递.脂质代谢脂质代谢是一种

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